Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloLong-Acting GLP-1 Receptor Agonist Exenatide Influence on the Autonomic Cardiac Sympatho-Vagal Balance
Anno di pubblicazione2018
  • Elettronico
  • Cartaceo
Autore/iCacciatori, Vittorio; Zoppini, Giacomo; Bellavere, Federico; Rigolon, Riccardo; Thomaseth, Karl; Pichiri, Isabella; Trombetta, Maddalena; Dauriz, Marco; De Santi, Francesca; Targher, Giovanni; Santi, Lorenza; Bonora, Enzo
Affiliazioni autoriUniv Verona; CNR
Autori CNR e affiliazioni
  • inglese
AbstractLong-acting glucagon-like peptide 1 receptor agonists are increasingly used to treat type 2 diabetes. An increase of heart rate (HR) has been observed with their use. To elucidate the role of the cardiac sympatho-vagal balance as a possible mediator of the reported increase in HR, we performed power spectral analysis of HR variability (HRV) in patients receiving exenatide extended-release (ER). Twenty-eight ambulatory patients with type 2 diabetes underwent evaluation at initiation of exenatide-ER and thereafter at 3 and at 6 months. To obtain spectral analyses of HRV, a computerized acquisition of 10 minutes of RR electrocardiogram intervals (mean values of 700 RR intervals) were recorded both in lying and in standing positions. All patients showed a substantial increase of HR both in lying and in standing positions. Systolic blood pressure, body weight, and glycated hemoglobin Alc significantly decreased both at 3 and 6 months compared with basal levels. The low-frequency/high-frequency ratio varied from 3.05 +/- 0.4 to 1.64 +/- 0.2 (P < 0.001) after 3 months and to 1.57 +/- 0.3 (P < 0.001) after 6 months in a lying position and from 4.56 +/- 0.8 to 2.24 +/- 0.3 (P < 0.001) after 3 months and to 2.38 0.4 (P < 0.001) after 6 months in a standing position compared with basal values, respectively. HR variations, induced by exenatide-ER treatment, do not appear to be related to sympathetic autonomic tone. Of note, we observed a relative increase of vagal influence on the heart. Copyright (C) 2018 Endocrine Society.
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da53
Pagine a62
Pagine totali10
RivistaJournal of the Endocrine Society
ISSN: 2472-1972
Titolo chiave: Journal of the Endocrine Society
Numero volume della rivista2
Fascicolo della rivista1
Verificato da refereeSì: Internazionale
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • ISI Web of Science (WOS) (Codice:000425356100005)
Parole chiaveautonomic nervous system, GLP-1 receptor agonist, power spectral analysis
Link (URL, URI)
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Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
Moduli/Attività/Sottoprogetti CNR
  • DIT.AD009.003.004 : MODBIO - Strumenti, metodi e applicazioni di modelli matematici di sistemi biologici dinamici
Progetti Europei-