Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloStimulated secretion of pituitary hormones in normal humans: A novel direct assessment from blood concentrations
Anno di pubblicazione2000
Formato-
Autore/iDe Nicolao, G; Liberati, D; Sartorio, A
Affiliazioni autoriUniv Pavia; CNR; IRCCS; IRCCS
Autori CNR e affiliazioni
  • DIEGO LIBERATI
Lingua/e
  • inglese
AbstractGland responsiveness is usually assessed by administering suitable secretagogues and measuring the resulting hormone concentration in blood after the specific stimulus. Such response-to-stimulus tests are routinely conducted for the clinical diagnosis of pathologies involving the pituitary hormones growth hormone, prolactin, luteinizing hormone, follicle stimulating hormone, adrenocorticotropic hormone, and thyrotropin hormone. However, the current evaluation approaches, based on the maximum peak value or the (normalized) area under the curve, are inadequate under several respects. A more physiologically based index of responsiveness is the amount of released hormone. This is not directly accessible but is typically estimated by (computationally expensive) deconvolution analysis. The present work derives a simple formula yielding the amount of released hormone as a linear combination of blood concentrations through proper weights depending on hormone kinetics and sampling protocol. The weights are derived and reported for all six pituitary hormones and the more common sampling protocols. A validation study involving 174 test experiments has been carried out. The use of the formula shows excellent agreement with the cumulative secretion estimates obtained through deconvolution analysis. (C) 2000 Biomedical Engineering Society. [S0090-6964(00)00709-8].
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da1136
Pagine a1145
Pagine totali10
RivistaAnnals of biomedical engineering
Attiva dal 1972
Editore: Pergamon Press. - New York
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0090-6964
Titolo chiave: Annals of biomedical engineering
Titolo proprio: Annals of biomedical engineering.
Titolo abbreviato: Ann. biomed. eng.
Numero volume della rivista28
Fascicolo della rivista9
DOI10.1114/1.1312185
Verificato da refereeSì: Internazionale
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • ISI Web of Science (WOS) (Codice:000165643700009)
Parole chiaveendocrinology, stimulated pituitary secretion, deconvolution, hormones, GH, PRL, LH, FSH, ACTH, TSH
Link (URL, URI)-
Titolo parallelo-
Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
Moduli/Attività/Sottoprogetti CNR
  • DIT.AD007.007.004 : ICSB - Information and Control for Systems Biology
Progetti Europei-
Allegati