Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloA combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: potential application for cardiovascular diseases
Anno di pubblicazione2018
FormatoElettronico
Autore/iMarrella, Alessandra; Iafisco, Michele; Adamiano, Alessio; Rossi, Stefano; Aiello, Maurizio; Barandalla-Sobrados, Maria; Carullo, Pierluigi; Miragoli, Michele; Tampieri, Anna; Scaglione, Silvia; Catalucci, Daniele
Affiliazioni autoriCNR; CNR; Univ Parma; CNR; Humanitas Clin & Res Ctr
Autori CNR e affiliazioni
  • ALESSANDRA MARRELLA
  • MICHELE MIRAGOLI
  • MAURIZIO AIELLO
  • DANIELE CATALUCCI
  • SILVIA SCAGLIONE
  • MICHELE IAFISCO
  • ANNA TAMPIERI
Lingua/e
  • inglese
AbstractAlternative drug delivery approaches to treat cardiovascular diseases are currently under intense investigation. In this domain, the possibility to target the heart and tailor the amount of drug dose by using a combination of magnetic nanoparticles (NPs) and electromagnetic devices is a fascinating approach. Here, an electromagnetic device based on Helmholtz coils was generated for the application of low-frequency magnetic stimulations to manage drug release from biocompatible superparamagnetic Fe-hydroxyapatite NPs (FeHAs). Integrated with a fluidic circuit mimicking the flow of the cardiovascular environment, the device was efficient to trigger the release of a model drug (ibuprofen) from FeHAs as a function of the applied frequencies. Furthermore, the biological effects on the cardiac system of the identified electromagnetic exposure were assessed in vitro and in vivo by acute stimulation of isolated adult cardiomyocytes and in an animal model. The cardio-compatibility of FeHAs was also assessed in vitro and in an animal model. No alterations of cardiac electrophysiological properties were observed in both cases, providing the evidence that the combination of low-frequency magnetic stimulations and FeHAs might represent a promising strategy for controlled drug delivery to the failing heart.
Lingua abstractinglese
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Pagine da-
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Pagine totali11
RivistaJournal of the Royal Society interface (Print)
Attiva dal 2004
Editore: The Royal Society, - London
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 1742-5689
Titolo chiave: Journal of the Royal Society interface (Print)
Titolo proprio: Journal of the Royal Society interface (Print)
Titolo alternativo: Interface (Print)
Numero volume della rivista15
Fascicolo della rivista144
DOI10.1098/rsif.2018.0236
Verificato da refereeSì: Internazionale
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • ISI Web of Science (WOS) (Codice:000440140600011)
Parole chiavebioreactor, cardiac cells, drug delivery, drug release, ELM stimulation, QRS complex
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Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
Moduli CNR-
Progetti Europei
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