Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
Titolo3D Porous Gelatin/PVA Hydrogel as Meniscus Substitute Using Alginate Micro-Particles as Porogens
Anno di pubblicazione2018
Autore/iMarrella, Alessandra; Lagazzo, Alberto; Dellacasa, Elena; Pasquini, Camilla; Finocchio, Elisabetta; Barberis, Fabrizio; Pastorino, Laura; Giannoni, Paolo; Scaglione, Silvia
Affiliazioni autoriIEIIT
Autori CNR e affiliazioni
  • inglese
AbstractOne of the current major challenges in orthopedic surgery is the treatment of meniscal lesions. Some of the main issues include mechanical consistency of meniscal implants, besides their fixation methods and integration with the host tissues. To tackle these aspects we realized a micro-porous, gelatin/polyvinyl alcohol (PVA)-based hydrogel to approach the high percentage of water present in the native meniscal tissue, recapitulating its biomechanical features, and, at the same time, realizing a porous implant, permissive to cell infiltration and tissue integration. In particular, we adopted aerodynamically-assisted jetting technology to realize sodium alginate micro-particles with controlled dimensions to be used as porogens. The porous hydrogels were realized through freezing-thawing cycles, followed by alginate particles leaching. Composite hydrogels showed a high porosity (74%) and an open porous structure, while preserving the elasticity behavior (E = 0.25 MPa) and high water content, typical of PVA-based hydrogels. The ex vivo animal model validation proved that the addition of gelatin, combined with the micro-porosity of the hydrogel, enhanced implant integration with the host tissue, allowing penetration of host cells within the construct boundaries. Altogether, these results show that the combined use of a water-insoluble micro-porogen and gelatin, as a bioactive agent, allowed the realization of a porous composite PVA-based hydrogel to be envisaged as a potential meniscal substitute.
Lingua abstractinglese
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Pagine totali16
RivistaPolymers (Basel)
Attiva dal 2009
Editore: Molecular Diversity Preservation International - Basel
Lingua: inglese
ISSN: 2073-4360
Titolo chiave: Polymers (Basel)
Titolo proprio: Polymers. (Basel)
Titolo abbreviato: Polymers (Basel)
Numero volume della rivista10
Fascicolo della rivista4
Verificato da refereeSì: Internazionale
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • ISI Web of Science (WOS) (Codice:000435087400038)
Parole chiavepolyvinyl alcohol, gelatin, meniscus, ex vivo culture, porous hydrogel, alginate micro-particles, porogen leaching
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Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
Moduli CNR
    Progetti Europei-