Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloModelling of the Current Density Distributions during Cortical Electric Stimulation for Neuropathic Pain treatment
Anno di pubblicazione2018
Autore/iFiocchi S., Chiaramello E., Ravazzani P., Parazzini M.
Affiliazioni autoriCNR Consiglio Nazionale delle Ricerche, Istituto di Elettronica e di Ingegneria dell'Informazione e delle Telecomunicazioni IEIIT, Milan, Italy
Autori CNR e affiliazioni
  • inglese
AbstractIn the last two decades, motor cortex stimulation has been recognized as a valuable alternative to pharmacological therapy for the treatment of neuropathic pain. Although this technique started to be used in clinical studies, the debate about the optimal settings that enhance its effectiveness without inducing tissue damage, is still open. To this purpose, computational approaches applied to realistic human models aimed to assess the current density distribution within the cortex, can be a powerful tool to provide a basic understanding of that technique and could help the design of clinical experimental protocols. This study aims to evaluate, by computational techniques, the current density distributions induced in the brain by a realistic electrode array for cortical stimulation. The simulation outcomes, summarized by specific metrics quantifying the efficacy of the stimulation (i.e. the effective volume and the effective depth of penetration) over two cortical targets, were evaluated by varying the inter-electrode distance, the stimulus characteristics (amplitude and frequency) and the anatomical human model. The results suggest that all these parameters somehow affect the current density distributions and have to be therefore taken into account during the planning of effective electrical cortical stimulation strategies. In particular, our calculations show that: 1) the most effective inter-electrode distance equals 2 cm; 2) increasing voltage amplitudes increases the effective volume; 3) increasing frequencies allow to enlarge the effective volume; 4) the effective depth of penetration is strictly linked to both the anatomy of the subject and the electrode placement.
Lingua abstractinglese
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RivistaComputational and mathematical methods in medicine (Online)
Attiva dal 2006
Editore: Hindawi - [Cairo]
Paese di pubblicazione: Egitto
Lingua: inglese
ISSN: 1748-6718
Titolo chiave: Computational and mathematical methods in medicine (Online)
Titolo proprio: Computational and mathematical methods in medicine (Online)
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Verificato da refereeSì: Internazionale
Stato della pubblicazionePreprint
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Parole chiaveMotor Cortex Stimulation, computational modelling, brain modelling, neuromodulation, electrodes
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Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
Moduli CNR-
Progetti Europei-
  • 2018 Fiocchi et al. Computational Math Meth Med
    Descrizione: PDF Version of the paper (in press)