Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloScaffold microstructure effects on functional and mechanical performance: Integration of theoretical and experimental approaches for bone tissue engineering applications.
Anno di pubblicazione2016
Autore/iCavo, Marta; Scaglione, Silvia
Affiliazioni autoria National Council of Research (CNR), IEIIT Institute, 16149 Genoa, Italy b University of Genoa, Polytechnic School, 16100 Genoa, Italy
Autori CNR e affiliazioni
  • inglese
AbstractThe really nontrivial goal of tissue engineering is combining all scaffold micro-architectural features, affecting both fluid-dynamical and mechanical performance, to obtain a fully functional implant. In this work we identified an optimal geometrical pattern for bone tissue engineering applications, best balancing several graft needs which correspond to competing design goals. In particular, we investigated the occurred changes in graft behavior by varying pore size (300mum, 600mum, 900mum), interpore distance (equal to pore size or 300mum fixed) and pores interconnection (absent, 45°-oriented, 90°-oriented). Mathematical considerations and Computational Fluid Dynamics (CFD) tools, here combined in a complete theoretical model, were carried out to this aim. Poly-lactic acid (PLA) based samples were realized by 3D printing, basing on the modeled architectures. A collagen (COL) coating was also realized on grafts surface and the interaction between PLA and COL, besides the protein contribution to graft bioactivity, was evaluated. Scaffolds were extensively characterized; human articular cells were used to test their biocompatibility and to evaluate the theoretical model predictions. Grafts fulfilled both the chemical and physical requirements. Finally, a good agreement was found between the theoretical model predictions and the experimental data, making these prototypes good candidates for bone graft replacements.
Lingua abstractinglese
Altro abstract-
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Pagine da872
Pagine a9
Pagine totali-
RivistaMaterials science & engineering. C, Biomimetic materials, sensors and systems (Print)
Attiva dal 1993
Editore: Elsevier Sequoia - Lausanne
Paese di pubblicazione: Paesi Bassi
Lingua: inglese
ISSN: 0928-4931
Titolo chiave: Materials science & engineering. C, Biomimetic materials, sensors and systems (Print)
Titolo proprio: Materials science & engineering. (Print)
Titolo abbreviato: Mater. sci. eng., C, Biomim. mater., sens. syst. (Print)
Titolo alternativo: Materials science and engineering. C, Biomimetic materials, sensors and systems (Print)
Numero volume della rivista68
Fascicolo della rivista-
Verificato da refereeSì: Internazionale
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • ISI Web of Science (WOS) (Codice:27524090)
Parole chiavetissue engineering, 3D printing, scaffold
Link (URL, URI)-
Titolo parallelo-
Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • IEIIT — IEIIT - Sede secondaria di Genova
Moduli CNR
  • INT.P02.002.004 : Approcci innovativi al tissue engineering
Progetti Europei-
PDF (documento privato )
Descrizione: PDF article
Tipo documento: application/pdf