Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloChemical and morphological gradient scaffolds to mimic hierarchically complex tissues: From theoretical modeling to their fabrication
Anno di pubblicazione2016
Autore/iAlessandra Marrella; Maurizio Aiello; Rodolfo Quarto; Silvia Scaglione
Affiliazioni autoriCNR-National Research Council of Italy, IEIIT Institute; Department of Experimental Medicine, University of Genoa
Autori CNR e affiliazioni
  • inglese
AbstractPorous multiphase scaffolds have been proposed indifferent tissue engineering applications because of their potentialto artificially recreate the heterogeneous structure of hierarchicallycomplex tissues. Recently, graded scaffolds have been also realized,offering a continuum at the interface among different phases for anenhanced structural stability of the scaffold. However, their internalarchitecture is often obtained empirically and the architecturalparameters rarely predetermined. The aim of this work is to offer atheoretical model as tool for the design and fabrication of functionaland structural complex graded scaffolds with predicted morpho-logical and chemical features, to overcome the time-consuming tr ialand error experimental method. This developed mathematicalmodel uses laws of motions, Stokes equations, and viscosity laws todescribe the dependence between centrifugation speed andfiber/particles sedimentation velocity over time, which finallyaffects the fiber packing, and thus the total porosity of the 3Dscaffolds. The efficacy of the theoretical model was tested byrealizing engineered graded grafts for osteochondral tissueengineering applications. The procedure, based on combinedcentrifugation and freeze-drying technique, was applied on bothpolycaprolactone (PCL) and collagen-t ype-I (COL) to test theversatilit y of the entire process. A functional gradient was combinedto the morphological one by adding hydroxyapatite (HA) powders,to mimic the bone mineral phase. Results show that 3D bioactivemorphologically and chemically graded graf ts can be properlydesigned and realized in agreement with the theoretical model.
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RivistaBiotechnology and bioengineering (Online)
Attiva dal 1962
Editore: John Wiley & Sons, Inc., - [New York, NY]
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1097-0290
Titolo chiave: Biotechnology and bioengineering (Online)
Titolo proprio: Biotechnology and bioengineering (Online)
Titolo abbreviato: Biotechnol. bioeng. (Online)
Titoli alternativi:
  • Biotechnology & bioengineering (Online)
  • Combinatorial chemistry (Online)
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Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)-
Parole chiavetissue engineering; theoretical modeling; bioengineering
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Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
Moduli CNR
    Progetti Europei-
    • Chemical and morphological gradient scaffolds to mimic hierarchically complex tissues: From theoretical modeling to their fabrication