Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloDimensional analysis of the electrical activity in fibrillating isolated hearts
Anno di pubblicazione1996
Formato
  • Elettronico
  • Cartaceo
Autore/iCasaleggio A.; Corana A.; Ranjan R.; Thakor N.V.
Affiliazioni autoriICE-CNR, Genova, Italy; ICE-CNR, Genova, Italy; Johns Hopkins University, Baltimore, MD, USA; Johns Hopkins University, Baltimore, MD, USA
Autori CNR e affiliazioni
  • ALDO CASALEGGIO
  • ANGELO CORANA
Lingua/e
  • inglese
AbstractThe dynamical behavior of the electrophysiological response at the epicardium of isolated Langendorff-perfused rabbit heart during different induced arrhythmic conditions is studied with the use of the correlation dimension D2 and Lyapunov exponents. Different conditions are investigated: normal sinus rhythm (NSR), normal sinus rhythm after ischemia (NSRI), and ventricular fibrillation with and without perfusion (VFWP and VF, respectively). Both single lead and simultaneous recordings from four leads are analyzed. The correlation dimensions during VF and VFWP are significantly higher than during NSR or NSRI, although low-dimensional attractors could not be clearly observed in VF and VFWP. Our conclusions are (a) that isolated hearts behave periodically during NSR, probably because the heart does not have to cope with time-varying demands either from the nervous system or from the metabolism; (b) during NSRI, spatially different regions of the heart show periodicities or chaotic behavior with low-dimensions, possibly due to electrophysiological inhomogeneity of the heart tissue; (c) during VF and VFWP, an intrinsic change in the dynamics seems to occur, and the heart behaves as a high-dimensional system, wherein VFWP signals show a greater spatial homogeneity than do VF signals. We propose a possible interpretation of the results in terms of the synchronization of cells by a pacemaker and desynchronization as a result of malignant arrhythmias.
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da1547
Pagine a1561
Pagine totali-
RivistaInternational journal of bifurcation and chaos in applied sciences and engineering
Attiva dal 1991
Editore: World Scientific. - Singapore
Paese di pubblicazione: Singapore
Lingua: inglese
ISSN: 0218-1274
Titolo chiave: International journal of bifurcation and chaos in applied sciences and engineering
Titolo abbreviato: Int. j. bifurc. chaos appl. sci. eng.
Numero volume della rivista6
Fascicolo della rivista8
DOI10.1142/S0218127496000916
Verificato da refereeSì: Internazionale
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • Scopus (Codice:2-s2.0-0030209385)
  • ISI Web of Science (WOS) (Codice:A1996VT00200009)
Parole chiavenonlinear time series analysis; dimensional analysis of heart signals; Lyapunov exponents; nornal sinus rhithm; ventricular fibrillation
Link (URL, URI)http://www.scopus.com/inward/record.url?eid=2-s2.0-0030209385&partnerID=q2rCbXpz
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Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • IEIIT — IEIIT - Sede secondaria di Genova
Moduli CNR-
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Allegati
  • Dimensional analysis of the electrical activity in fibrillating isolated hearts