Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloExtremely low-frequency magnetic fields and risk of childhood leukemia: A risk assessment by the ARIMMORA consortium
Anno di pubblicazione2016
FormatoElettronico
Autore/iSchuz J.; Dasenbrock C.; Ravazzani P.; Roosli M.; Schar P.; Bounds P.L.; Erdmann F.; Borkhardt A.; Cobaleda C.; Fedrowitz M.; Hamnerius Y.; Sanchez-Garcia I.; Seger R.; Schmiegelow K.; Ziegelberger G.; Capstick M.; Manser M.; Muller M.; Schmid C.D.; Schurmann D.; Struchen B.; Kuster N.
Affiliazioni autoriSection of Environment and Radiation, International Agency for Research on Cancer (IARC), Lyon, France; Fraunhofer ITEM, Hanover, Germany; National Research Council of Italy, Institute of Electronics, Computer and Telecommunication Engineering, Milan, Italy; University of Basel and Swiss Tropical and Public Health Institute, Basel, Switzerland; Department of Biomedicine, University of Basel, Basel, Switzerland; IT'IS: Foundation for Research on Information Technologies in Society, Zürich, Switzerland; Medical Faculty, Department of Pediatric Oncology, Haematology and Clinical Immunology, Heinrich-Heine University, Düsseldorf, Germany; Spanish National Research Council (CSIC), Centro de Biología Molecular Severo Ochoa, Madrid, Spain; University of Veterinary Medicine, Hanover, Germany; Chalmers University of Technology, Gothenburg, Sweden; Spanish National Research Council (CSIC), Instituto de Biologia Molecular y Celular del Cancer, Salamanca, Spain; Weizmann Institute of Science, Rehovat, Israel; University Hospital, Copenhagen, Denmark; German Federal Office for Radiation Protection, Neuherberg, Germany
Autori CNR e affiliazioni
  • PAOLO GIUSEPPE RAVAZZANI
Lingua/e
  • inglese
AbstractExposure to extremely low-frequency magnetic fields (ELF-MF) was evaluated in an International Agency for Research on Cancer (IARC) Monographs as "possibly carcinogenic to humans" in 2001, based on increased childhood leukemia risk observed in epidemiological studies. We conducted a hazard assessment using available scientific evidence published before March 2015, with inclusion of new research findings from the Advanced Research on Interaction Mechanisms of electroMagnetic exposures with Organisms for Risk Assessment (ARIMMORA) project. The IARC Monograph evaluation scheme was applied to hazard identification. In ARIMMORA for the first time, a transgenic mouse model was used to mimic the most common childhood leukemia: new pathogenic mechanisms were indicated, but more data are needed to draw definitive conclusions. Although experiments in different animal strains showed exposure-related decreases of CD8+ T-cells, a role in carcinogenesis must be further established. No direct damage of DNA by exposure was observed. Overall in the literature, there is limited evidence of carcinogenicity in humans and inadequate evidence of carcinogenicity in experimental animals, with only weak supporting evidence from mechanistic studies. New exposure data from ARIMMORA confirmed that if the association is nevertheless causal, up to 2% of childhood leukemias in Europe, as previously estimated, may be attributable to ELF-MF. In summary, ARIMMORA concludes that the relationship between ELF-MF and childhood leukemia remains consistent with possible carcinogenicity in humans. While this scientific uncertainty is dissatisfactory for science and public health, new mechanistic insight from ARIMMORA experiments points to future research that could provide a step-change in future assessments.
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da183
Pagine a189
Pagine totali-
RivistaBioelectromagnetics
Attiva dal 1980
Editore: Wiley-Liss, Inc. - Hoboken, NJ,
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0197-8462
Titolo chiave: Bioelectromagnetics
Titolo proprio: Bioelectromagnetics.
Titolo abbreviato: Bioelectromagnetics
Titolo alternativo: Bio electro magnetics
Numero volume della rivista37
Fascicolo della rivista3
DOI10.1002/bem.21963
Verificato da refereeSì: Internazionale
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • Scopus (Codice:2-s2.0-84961215566)
Parole chiaveAdverse effects, Children, Electromagnetic fields, Hazard identification, Leukemia, Risk assessment
Link (URL, URI)http://www.scopus.com/inward/record.url?eid=2-s2.0-84961215566&partnerID=q2rCbXpz
Titolo parallelo-
Data di accettazione19/02/2016
Note/Altre informazioni-
Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
Moduli CNR-
Progetti Europei
Allegati
PDF version of the paper (documento privato )
Tipo documento: application/pdf

Dati associati a vecchie tipologie
I dati associati a vecchie tipologie non sono modificabili, derivano dal cambiamento della tipologia di prodotto e hanno solo valore storico.
Citazione bibliograficaSchüz J., Dasenbrock C., Ravazzani P., Röösli M., Schär P., Bounds P.L., Erdmann F., Borkhardt A., Cobaleda C., Fedrowitz M., Hamnerius Y., ?Sanchez-Garcia I., Seger R., Schmiegelow K., ? Ziegelberger G., Capstick M., Manser M., Müller M., Schmid C.D., Schürmann D.,5 Struchen B., Kuster N. .: Extremely Low-Frequency Magnetic Fields and Risk of Childhood Leukemia: A Risk Assessment by the ARIMMORA Consortium, Bioelectromagnetics, 37: pp. 183-189, 2016.