Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloThe Interplay of Intrinsic and Extrinsic Bounded Noises in Biomolecular Networks
Anno di pubblicazione2013
Autore/iCaravagna G.; Mauri G.; d'Onofrio A.
Affiliazioni autoriDipartimento di Informatica, Sistemistica e Comunicazione, Università degli Studi Milano-Bicocca, Milan, Italy; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
Autori CNR e affiliazioni
  • inglese
AbstractAfter being considered as a nuisance to be filtered out, it became recently clear that biochemical noise plays a complex role, often fully functional, for a biomolecular network. The influence of intrinsic and extrinsic noises on biomolecular networks has intensively been investigated in last ten years, though contributions on the co-presence of both are sparse. Extrinsic noise is usually modeled as an unbounded white or colored gaussian stochastic process, even though realistic stochastic perturbations are clearly bounded. In this paper we consider Gillespie-like stochastic models of nonlinear networks, i.e. the intrinsic noise, where the model jump rates are affected by colored bounded extrinsic noises synthesized by a suitable biochemical state-dependent Langevin system. These systems are described by a master equation, and a simulation algorithm to analyze them is derived. This new modeling paradigm should enlarge the class of systems amenable at modeling. We investigated the influence of both amplitude and autocorrelation time of a extrinsic Sine-Wiener noise on: (i) the Michaelis-Menten approximation of noisy enzymatic reactions, which we show to be applicable also in co-presence of both intrinsic and extrinsic noise, (ii) a model of enzymatic futile cycle and (iii) a genetic toggle switch. In (ii) and (iii) we show that the presence of a bounded extrinsic noise induces qualitative modifications in the probability densities of the involved chemicals, where new modes emerge, thus suggesting the possible functional role of bounded noises. © 2013 Caravagna et al.
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RivistaPloS one
Attiva dal 2006
Editore: Public Library of Science - San Francisco, CA
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1932-6203
Titolo chiave: PloS one
Titolo proprio: PloS one
Titolo abbreviato: PLoS ONE
Titoli alternativi:
  • Public Library of Science one
  • PLoS 1
Numero volume della rivista8
Fascicolo della rivista2
Verificato da refereeSì: Internazionale
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • Scopus (Codice:2-s2.0-84874335766)
Parole chiavealgorithm; article; calculation
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Note/Altre informazioniL'attività descritta nella pubblicazione è stata svolta nell'ambito della associatura IEIIT-CNR
Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
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