Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloIn vivo lamellar bone formation in fibre coated MgCHA-PCL-composite scaffolds
Anno di pubblicazione2012
Autore/iScaglione, Silvia; Guarino, Vincenzo; Sandri, Monica; Tampieri, Anna; Ambrosio, Luigi; Quarto, Rodolfo
Affiliazioni autoriCNR-National Research Council of Italy, IEIIT Institute,Genoa, Italy National Research Council (CNR), Institute of Composite and Biomedical Materials (IMCB), Naples, Italy CNR-National Research Council of Italy, Institute of Science and Technology for Ceramic Materials (ISTEC), Faenza, Italy Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy
Autori CNR e affiliazioni
  • inglese
AbstractBio-inspired materials with controlled topography have gained increasing interest in regenerative medicine, because of their ability to reproduce the physical features of natural extracellular matrix, thus amplifying certain biological responses both in vitro and in vivo, such as contact guidance and differentiation. However, information on the ability to adapt this high cell potential to 3D scaffolds, effective to be implanted in clinical bone defect, is still missing. Here, we examine the pattern of bone tissue generated within the implant in an ectopic model, seeding bone marrow progenitor cells onto PCL-MgCHA scaffolds. This composite material presented a porous structure with micro/nanostructured surfaces obtained by combining phase inversion/salt leaching and electrospinning techniques. Histological analysis of grafts harvested after 1-2-6 months from implantation highlights an extent of lamellar bone tissue within interconnected pores of fibre coated PCL-MgCHA composites, whereas uncoated scaffolds displayed sparse deposition of bone. Pure PCL scaffolds did not reveal any trace of bone for the overall 6 months of observation. In conclusion, we show that a structural modification in scaffold design is able to enhance bone regeneration possibly mimicking some physiological cues of the natural tissue.
Lingua abstractinglese
Altro abstract-
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Pagine da117
Pagine a128
Pagine totali12
RivistaJournal of materials science. Materials in medicine
Attiva dal 1990
Editore: Chapman and Hall. - London
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0957-4530
Titolo chiave: Journal of materials science. Materials in medicine
Titolo abbreviato: J. mater. sci., Mater. med.
Numero volume della rivista23
Fascicolo della rivista1
Verificato da refereeSì: Internazionale
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • ISI Web of Science (WOS) (Codice:000299724300014)
Parole chiavebone regerenation, composite scaffold, PCL, hydroxyapatite
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Data di accettazione-
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Strutture CNR
  • IEIIT — IEIIT - Sede secondaria di Genova
  • IMCB — Istituto per i materiali compositi e biomedici
  • ISTEC — Istituto di scienza e tecnologia dei materiali ceramici
Moduli CNR
    Progetti Europei-
    • In vivo lamellar bone formation in fibre coated MgCHA-PCL-composite scaffolds