Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloPharmacokinetics and pharmacodynamics of protamine zinc recombinant human insulin in healthy dogs
Anno di pubblicazione2012
Autore/iClark, M.; Thomaseth, K.; Heit, M.; Hoenig, M.,
Affiliazioni autori1: Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, IL, USA / 2: Corso Stati Uniti 4, Institute of Biomedical Engineering - ISIB, CNR - National Research Council of Italy, Padova, Italy / 3: Boehringer-Ingelheim Vetmedica, North Belt Highway, St Joseph, MO, USA / 4: Department of Veterinary Clinical Medicine, University of Illinois College of Veterinary Medicine, Urbana, IL, USA
Autori CNR e affiliazioni
  • inglese
AbstractProtamine zinc insulins are generally considered to be long acting, with slow absorption from subcutaneous tissue. Protamine zinc recombinant human insulin (PZIR) may be useful to treat diabetic dogs. The purpose of this study was to describe the pharmacokinetics and pharmacodynamics of PZIR in dogs. PZIR was administered subcutaneously to 10 healthy Beagles using an incomplete crossover design, at doses of 0.3 or 0.5 U/ kg (each n = 5), 0.8 U/ kg (n = 10), or 0.8 U/ kg at three separate sites (n = 6). Insulin and glucose concentrations were measured over 24 h. The shapes of insulin and glucose curves were variable among dogs, and the relationship between insulin dose, concentration, and glucose-lowering effect was nonlinear. For single-site 0.8 U/ kg, median (range) onset of action was 3.5 h (0.5-10 h), time to glucose nadir was 14 h (5 to >24 h), and duration of action was >24 h (16 to >24 h). Mathematical model predictions of times to 50% and 90% insulin absorption, and fraction of insulin absorbed in 24 h, were not significantly different among protocols. Results confirm the tendency toward a late onset and long duration of action for PZIR in dogs. This insulin may be an alternative treatment option for diabetic dogs.
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da342
Pagine a350
Pagine totali-
RivistaJournal of veterinary pharmacology and therapeutics (Print)
Attiva dal 1978
Editore: Blackwell, - Oxford
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0140-7783
Titolo chiave: Journal of veterinary pharmacology and therapeutics (Print)
Titolo proprio: Journal of veterinary pharmacology and therapeutics (Print)
Titolo abbreviato: J. vet. pharmacol. ther. (Print)
Numero volume della rivista35
Fascicolo della rivista4
Verificato da refereeSì: Internazionale
Stato della pubblicazione-
Indicizzazione (in banche dati controllate)
  • ISI Web of Science (WOS) (Codice:000306006100004)
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Titolo parallelo-
Data di accettazione-
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Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
  • ISIB — Istituto di ingegneria biomedica
Moduli CNR
    Progetti Europei-
    • Pharmacokinetics and pharmacodynamics of protamine zinc recombinant human insulin in healthy dogs

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