Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloFatty acid turnover, substrate oxidation, and heat production in lean and obese cats during the euglycemic hyperinsulinemic clamp
Anno di pubblicazione2007
Formato-
Autore/iHoenig, M.; Thomaseth, K.; Waldron, M.; Ferguson, D.
Affiliazioni autori1, 4: Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, Athens, GA, United States; 2: Institute of Biomedical Engineering of the Italian National Research Council, Padova, Italy; 3: Nestle Purina Co., St. Louis, MO, United States
Autori CNR e affiliazioni
  • KARL THOMASETH
Lingua/e-
AbstractSimultaneous application of the euglycemic hyperinsulinemic clamp (EHC) and indirect calorimetry was used to examine heat production, fat, and glucose metabolism in lean and obese adult neutered male and female cats. The results show that in lean insulin-sensitive cats glucose oxidation predominated during fasting, whereas lipid oxidation became more prominent in obese cats. Insulin infusion during the EHC in lean cats and obese male cats led to a large increase in glucose oxidation, glycogenesis, and lipogenesis. It also led to an increase in glucose oxidation and glycogenesis in obese female cats but it was significantly less compared to lean cats and obese males. This indicates that obese females show greater metabolic inflexibility. In obese cats of either gender, insulin caused greater suppression of non-esterified fatty acids compared to lean cats suggesting that obese cats show greater fatty acid clearance than lean cats. The heat production per metabolic size was lower in obese cats than lean cats. This would perpetuate obesity unless food intake is decreased. The higher glucose oxidation rate in obese neutered male cats suggests that they are able to replete their glycogen and lipid stores at a faster rate than females in response to insulin and it implies that they gain weight more rapidly. Further studies are needed to investigate if the different response to insulin of male cats is involved in their higher risk to develop diabetes.
Lingua abstract-
Altro abstract-
Lingua altro abstract-
Pagine da329
Pagine a338
Pagine totali-
RivistaDomestic animal endocrinology
Attiva dal 1984
Editore: Domendo, - [Auburn, Ala.]
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0739-7240
Titolo chiave: Domestic animal endocrinology
Titolo proprio: Domestic animal endocrinology.
Titolo abbreviato: Domest. anim. endocrinol.
Numero volume della rivista32
Fascicolo della rivista-
DOI10.1016/j.domaniend.2006.04.003
Verificato da refereeSì: Internazionale
Stato della pubblicazione-
Indicizzazione (in banche dati controllate)
  • Scopus (Codice:2-s2.0-33947225232)
  • ISI Web of Science (WOS) (Codice:000245414500007)
Parole chiaveEuglycemic hyperinsulinemic clamp, Indirect calorimetry, Obesity, Diabetes, Cats
Link (URL, URI)http://www.ncbi.nlm.nih.gov/pubmed/16687234
Titolo parallelo-
Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
  • ISIB — Istituto di ingegneria biomedica
Moduli CNR
    Progetti Europei-
    Allegati

      Dati storici
      I dati storici non sono modificabili, sono stati ereditati da altri sistemi (es. Gestione Istituti, PUMA, ...) e hanno solo valore storico.
      Rivista ISIDOMESTIC ANIMAL ENDOCRINOLOGY [06151J0]