Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloEffect of aspirin on phase gradient of 2F1-F2 distortion product otoacoustic emission
Anno di pubblicazione2005
  • Elettronico
  • Cartaceo
Autore/iParazzini M., Hall A. J., Lutman M. E., and Kapadia S.
Affiliazioni autoriParazzin M: Istituto di Ingegneria Biomedica ISIB, CNR, Milan, Piazza Leonardo da Vinci 32, 20133 Milano, Italy Hall AJ, Lutman ME, Kapadia S: Institute of Sound and Vibration Research, University of Southampton, UK
Autori CNR e affiliazioni
  • inglese
AbstractIt is well known that aspirin consumption temporarily reduces overall otoacoustic emission (OAE) amplitude in humans. However, little is known about changes in the separate components of distortion product otoacoustic emissions (DPOAE), which may be distinguished by examining phase gradients. The effects of aspirin on the phase gradient of the DPOAE 2F1-F2 obtained with fixed frequency ratio sweeps were studied longitudinally in a group of twelve subjects in whom a temporary hearing loss was induced by aspirin consumption. DPOAE were recorded daily for two days pre-aspirin consumption, during the three days of aspirin consumption and two days afterwards. DP-grams were recorded over a restricted frequency range centered on 2, 3, 4 and 6 kHz with the following stimulus levels: L1/L2 of 60/50-80/70 in 10-dB steps. The effects of aspirin on the phase gradients varied between the subjects and across frequency: the general trend was that the phase gradient became steeper across successive sessions for the higher frequencies, while no significant effect was found at the lower frequencies. These results suggest that aspirin may have more persistent effects on cochlear function than are disclosed by measurements of hearing threshold level or DPOAE amplitude. Particularly, DPOAE phase gradient appears to be increased by aspirin consumption and has not recovered two days after cessation of aspirin intake, despite almost complete recovery of DPOAE amplitude and hearing threshold levels. These findings may suggest differential effects on the distortion and reflection mechanisms considered to underlie DPOAE generation.
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da44
Pagine a52
Pagine totali-
RivistaHearing research
Attiva dal 1978
Editore: Elsevier - Shannon ;
Paese di pubblicazione: Paesi Bassi
Lingua: inglese
ISSN: 0378-5955
Titolo chiave: Hearing research
Titolo abbreviato: Hear. res.
Numero volume della rivista205
Fascicolo della rivista1-2
Verificato da refereeSì: Internazionale
Stato della pubblicazione-
Indicizzazione (in banche dati controllate)
  • ISI Web of Science (WOS) (Codice:WOS:000230239400005)
  • Scopus (Codice:s2.0-20444448067)
Parole chiaveDistortion product otoacoustic emissions;Aspirin; Phase gradient
Link (URL, URI)
Titolo parallelo-
Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
  • ISIB — Istituto di ingegneria biomedica
Moduli/Attività/Sottoprogetti CNR
  • ME.P06.021.001 : Neuroingegneria e disordini della comunicazione
Progetti Europei-
Effect of aspirin on phase gradient of 2F1-F2 distortion product otoacoustic emissions (documento privato )
Tipo documento: application/x-download

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