Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloBasal and dynamic proinsulin-insulin relationship to assess beta-cell function during OGTT in metabolic disorders
Anno di pubblicazione2003
FormatoCartaceo
Autore/iTura, A.; Pacini, G.; Kautzky-Willer, A.; Ludvik, B.; Prager, R.; Thomaseth, K.
Affiliazioni autori1, 2, 6: Metabolic Unit, Institute of Biomedical Engineering, National Research Council, 35127 Padua, Italy; 3, 4, 5: Division of Endocrinology and Metabolism, Department of Medicine 3, University of Vienna Medical School, A-1090 Vienna, Austria
Autori CNR e affiliazioni
  • ANDREA TURA
  • GIOVANNI PACINI
  • KARL THOMASETH
Lingua/e
  • inglese
AbstractThe fasting proinsulin-to-insulin ratio is a currently used marker of -cell dysfunction. This ratio is calculated at the basal condition, but its behavior in dynamic conditions, i.e., during glucose stimulation, could be more informative. Given the different kinetics of the peptides, a mathematical model was necessary to analyze the oral glucose tolerance test (OGTT) data of insulin, C-peptide, and proinsulin in 55 healthy (NGT), 30 impaired glucose-tolerant (IGT), and 31 type 2 diabetic (T2DM) subjects. The model provided for secretion and disappearance of the peptides and an index of -cell function under dynamic conditions. Total proinsulin secretion during the OGTT was not different (P  0.053) among NGT (0.17  0.01 mmol/l in 3 h), IGT (0.22  0.02), and T2DM (0.21  0.02) subjects. The proinsulin-to-insulin molar ratio measured from basal samples was higher (P  0.0001) in T2DM (0.39  0.05) than in NGT (0.14  0.01) and IGT (0.13  0.02) subjects, and similar results (P  0.003) were found by the dynamic index (0.27  0.04, 0.14  0.01, 0.15  0.01 in T2DM, NGT, IGT subjects, respectively). The basal ratio significantly correlated with the dynamic index, and the regression line slope was lower than 1 (0.43  0.08, 0.61  0.10, and 0.56  0.03 in NGT, IGT, and T2DM subjects, respectively, P  0.0001). Impaired -cell function in T2DM could then be indicated by proinsulin-to-insulin indexes at both basal and dynamic phases
Lingua abstract-
Altro abstract-
Lingua altro abstract-
Pagine daE155
Pagine aE162
Pagine totali-
RivistaAmerican journal of physiology: endocrinology and metabolism
Attiva dal 1980 al 2011
Editore: American Physiological Society - Bethesda, MD
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0193-1849
Titolo chiave: American journal of physiology: endocrinology and metabolism
Titolo proprio: American journal of physiology.
Titolo abbreviato: Am. j. physiol: endocrinol. metab.
Titolo alternativo: Endocrinology and metabolism
Numero volume della rivista285
Fascicolo della rivista-
DOI10.1152/ajpendo.00104.2002
Verificato da refereeSì: Internazionale
Stato della pubblicazione-
Indicizzazione (in banche dati controllate)
  • ISI Web of Science (WOS) (Codice:000183629300018)
Parole chiaveproinsulin secretion, proinsulin clearance, impaired glucose tolerance, type 2 diabetes, mathematical modeling
Link (URL, URI)http://www.ncbi.nlm.nih.gov/pubmed/12670835
Titolo parallelo-
Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
  • ISIB — Istituto di ingegneria biomedica
Moduli CNR
    Progetti Europei-
    Allegati

      Dati storici
      I dati storici non sono modificabili, sono stati ereditati da altri sistemi (es. Gestione Istituti, PUMA, ...) e hanno solo valore storico.
      Rivista ISIAMERICAN JOURNAL OF PHYSIOLOGY [07964J0]