Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloElastin-Coated Biodegradable Photopolymer Scaffolds for Tissue Engineering Applications
Anno di pubblicazione2014
Formato
  • Elettronico
  • Cartaceo
Autore/iRossella Barenghi 1; Szabolcs Beke 2; Ilaria Romano 2; Paola Gavazzo 3; Balázs Farkas 2; Massimo Vassalli 3; Fernando Brandi 2,4; Silvia Scaglione 1
Affiliazioni autori1 National Research Council of Italy (CNR), IEIIT Institute, Via De Marini 6, 16149 Genova, Italy 2Department of Nanophysics, Istituto Italiano di Tecnologia (IIT), Via Morego 30, 16163 Genova, Italy 3National Research Council of Italy (CNR), IBF Institute, Via De Marini 6, 16149 Genova, Italy 4National Research Council of Italy (CNR), INO Institute, Via Moruzzi 1, 56124 Pisa, Italy
Autori CNR e affiliazioni
  • ROSSELLA BARENGHI
  • PAOLA GAVAZZO
  • MASSIMO VASSALLI
  • SILVIA SCAGLIONE
  • FERNANDO BRANDI
Lingua/e
  • inglese
AbstractOne of the main open issues in modern vascular surgery is the nonbiodegradability of implants used for stent interventions, which can lead to small caliber-related thrombosis and neointimal hyperplasia. Some new, resorbable polymeric materials have been proposed to substitute traditional stainless-steel stents, but so far they were affected by poor mechanical properties and low biocompatibility. In this respect, a new material, polypropylene fumarate (PPF), may be considered as a promising candidate to implement the development of next generation stents, due to its complete biodegradability, and excellent mechanical properties and the ease to be precisely patterned. Besides all these benefits, PPF has not been tested yet for vascular prosthesis,mainly because it proved to be almost inert, while the ability to elicit a specific biological function would be of paramount importance in such critical surgery applications. Here, we propose a biomimetic functionalization process, aimed at obtaining specific bioactivation and thus improved cell-polymer interaction. Porous PPF-based scaffolds produced by deep-UV photocuring were coated by elastin and the functionalized scaffolds were extensively characterized, revealing a stable bound between the protein and the polymer surface. Both 3T3 and HUVEC cell lines were used for in vitro tests displaying an enhancement of cells adhesion and proliferation on the functionalized scaffolds.
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine daart_n_624645
Pagine a-
Pagine totali9
RivistaBioMed Research International (Online)
Attiva dal 2012
Editore: Hindawi Publishing Corporation - Cairo
Paese di pubblicazione: Egitto
Lingua: inglese
ISSN: 2314-6141
Titolo chiave: BioMed Research International (Online)
Titolo proprio: BioMed Research International
Titolo abbreviato: BioMed Res. Int.
Numero volume della rivista-
Fascicolo della rivista-
DOI10.1155/2014/624645
Verificato da refereeSì: Internazionale
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • ISI Web of Science (WOS) (Codice:000346989400001)
  • Scopus (Codice:2-s2.0-84911164459)
Parole chiavepolypropylene fumarate
Link (URL, URI)http://dx.doi.org/10.1155/2014/624645
Titolo parallelo-
Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • IBF — Istituto di biofisica
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
  • INO — INO - Sede secondaria di Pisa
Moduli CNR
    Progetti Europei-
    Allegati