Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloA novel scaffold geometry for chondral applications: Theoretical model and in vivo validation.
Anno di pubblicazione2014
Autore/iScaglione, Silvia; Ceseracciu, Luca; Aiello, Maurizio; Coluccino, Luca; Ferrazzo, Federica; Giannoni, Paolo; Quarto, Rodolfo
Affiliazioni autoriIEIIT-Research National Council (CNR), Via De Marini 6, Genoa, 16149, Italy.
Autori CNR e affiliazioni
  • inglese
AbstractA theoretical model of the 3D scaffold internal architecture has been implemented with the aim to predict the effects of some geometrical parameters on total porosity, Young modulus, buckling resistance and permeability of the graft. This model has been adopted to produce porous poly-caprolacton based grafts for chondral tissue engineering applications, best tuning mechanical and functional features of the scaffolds. Material prototypes were produced with an internal geometry with parallel oriented cylindrical pores of 200mum of radius (r) and an interpore distance/pores radius (d/r) ratio of 1. The scaffolds have been then extensively characterized; progenitor cells were then used to test their capability to support cartilaginous matrix deposition in an ectopic model. Scaffold prototypes fulfill both the chemical-physical requirements, in terms of Young's modulus and permeability, and the functional needs, such as surface area per volume and total porosity, for an enhanced cellular colonization and matrix deposition. Moreover, the grafts showed interesting chondrogenic potential in vivo, besides offering adequate mechanical performances in vitro, thus becoming a promising candidate for chondral tissues repair. Finally, a very good agreement was found between the prediction of the theoretical model and the experimental data. Many assumption of this theoretical model, hereby applied to cartilage, may be transposed to other tissue engineering applications, such as bone substitutes. Biotechnol. Bioeng. 2014;111: 2107-2119. 2014 Wiley Periodicals, Inc.
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da2107
Pagine a2119
Pagine totali-
RivistaBiotechnology and bioengineering (Online)
Attiva dal 1962
Editore: John Wiley & Sons, Inc., - [New York, NY]
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1097-0290
Titolo chiave: Biotechnology and bioengineering (Online)
Titolo proprio: Biotechnology and bioengineering (Online)
Titolo abbreviato: Biotechnol. bioeng. (Online)
Titoli alternativi:
  • Biotechnology & bioengineering (Online)
  • Combinatorial chemistry (Online)
Numero volume della rivista111
Fascicolo della rivista10
Verificato da refereeSì: Internazionale
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • ISI Web of Science (WOS) (Codice:25073412)
Parole chiavetissue engineering; materials; bioeingineering
Link (URL, URI)-
Titolo parallelo-
Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
Moduli CNR
  • INT.P02.002.004 : Approcci innovativi al tissue engineering
Progetti Europei-