Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloDiagnostic value of mesothelin in pleural fluids: Comparison with CYFRA 21-1 and CEA
Anno di pubblicazione2013
Autore/iFiliberti R.; Parodi S.; Libener R.; Ivaldi G.P.; Canessa P.A.; Ugolini D.; Bobbio B.; Marroni P.
Affiliazioni autoriEpidemiology, Biostatistics and Clinical Trials, IRCCS AOU San Martino-IST, Largo R. Benzi, 10, Genoa 16132, Italy; Institute of Electronics, Computer and Telecommunication Engineering, Genoa, Italy; Pathology Unit, Azienda Ospedaliera Nazionale SS, Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Department of Pneumology, AO Villa Scassi, Genoa, Italy; Unit of Pneumology, Ospedale San Bartolomeo, Sarzana, Italy; Department of Internal Medicine, University of Genova and Epidemiology, Biostatistics and Clinical Trials, IRCCS AOU San Martino-IST, Genoa, Italy; Department of Laboratory Medicine, IRCCS AOU San Martino-IST, Genoa, Italy
Autori CNR e affiliazioni
  • inglese
AbstractCYFRA 21-1 and CEA have been applied for the differential diagnosis of malignant pleural mesothelioma (MPM). The soluble mesothelin-related peptide (SMRP) has been proposed as a specific marker for distinguishing MPM from benign diseases and other malignancies in pleural effusions (PEs). In this study, we evaluated the usefulness of SMRP in PEs in the detection of mesotheliomas by comparing it with that of CYFRA 21-1, CEA, and with cytological examination. One hundred and seventy-seven consecutive patients (57 MPM, 64 metastatic tumors, and 56 benign diseases) were evaluated using commercial tests. The performance of the markers was analyzed by standard ROC analysis methods, using the area under a ROC curve (AUC) as a measure of accuracy. CYFRA 21-1 better differentiated malignant from benign effusions. The corresponding area under the receiver operating characteristic curve was 0.87, while it was 0.74 for SMRP and 0.64 for CEA (p < 0.001). Conversely, SMRP differentiated MPM from all other PEs better than both CYFRA 21-1 and CEA (AUC = 0.84, 0.76, and 0.32, respectively, p = 0.003). Low levels of CEA were associated with a MPM diagnosis. The AUC for differentiating MPM from metastases was 0.81 for SMRP, 0.61 for CYFRA 21-1, and 0.20 for CEA (p < 0.001). In cases with negative or suspicious cytology, SMRP and CYFRA 21-1 identified 36/71 and 46/66 malignant PEs (29 and 31 MPM, respectively). Only 1 MPM showed a high CEA concentration. No single marker showed the best performance in any comparison. Results suggest that SMRP could improve CYFRA 21-1 and CEA accuracy in the differential diagnosis of MPM. © 2013 Springer Science+Business Media New York.
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RivistaMedical oncology (Northwood)
Attiva dal 1994
Editore: Science and Technology letters. - Northwood
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 1357-0560
Titolo chiave: Medical oncology (Northwood)
Titolo abbreviato: Med. oncol. (Northwood)
Numero volume della rivista30
Fascicolo della rivista2
Verificato da refereeSì: Internazionale
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • Scopus (Codice:2-s2.0-84875356282)
Parole chiaveDiagnosis, Marker, Mesothelioma, Pleural effusion, ROC curves
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  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
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  • Diagnostic value of mesothelin in pleural fluids: Comparison with CYFRA 21-1 and CEA