Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloSeasonal variations of date of diagnosis and birth for neuroblastoma patients in Italy.
Anno di pubblicazione2013
Autore/iParodi S, Fontana V, Haupt R, Corrias MV.
Affiliazioni autoriInstitute of Electronics, Computer and Telecommunication Engineering, National Research Council of Italy, Via De Marini 6, Genoa, Italy Unit of Epidemiology, Biostatistics and Clinical Trials, IRCCS AOU San Martino-IST, L.go R. Benzi, 10, Genoa, Italy Epidemiology and Biostatistics Section, Scientific Directorate, IRCCS Istituto Giannina Gaslini, L.go G. Gaslini, 5, Genoa, Italy Laboratory of Oncology, and Department of Hematology-Oncology, IRCCS Istituto Giannina Gaslini, L.go G. Gaslini, 5, Genoa, Italy
Autori CNR e affiliazioni
  • inglese
AbstractBackground: Analysis of seasonal variation of diagnosis or birth of childhood cancers may provide useful insight about possible aetiological risk factors, such as infectious agents and environmental exposures, but studies on neuroblastoma are lacking. Procedure: Two thousand seven hundred fifty-six cases of neuroblastoma, diagnosed between 1980 and 2010, registered in the Italian Neuroblastoma Registry, were included in the study. Subgroup analyses were carried out by age, gender and stage at diagnosis. Seasonal trend was assessed by a harmonic function in a Poisson regression model, adjusted for the number of live births. Results: No trend in the date of diagnosis was found either in the entire cohort or in the various subgroups. Similarly, a seasonal trend of birth was not observed in the whole cohort. Conversely, in the subgroup of infants with stage 4S, a significant peak of July births was found (23.6% increment from the average, p = 0.042). The summer peak was confirmed after stratifying 4S patients by gender and period of diagnosis. Conclusions: A major effect of risk factors related to seasonality does not appear to affect the risk of developing neuroblastoma. However, the time pattern of birth observed by stage at diagnosis is consistent with the hypothesis that Stage 4S is a distinct disease with probably a different aetiology, as indicated by investigations on its metastatic pattern and its peculiar gene expression. An aetiological role of seasonally related factors, e.g., favouring the survival of defective neural crest stem cells, remains speculative and need confirmation by independent studies.
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da575
Pagine a578
Pagine totali4
RivistaCancer epidemiology (Print)
Attiva dal 2009
Editore: Elsevier Science - Amsterdam
Paese di pubblicazione: Paesi Bassi
Lingua: inglese
ISSN: 1877-7821
Titolo chiave: Cancer epidemiology (Print)
Titolo proprio: Cancer epidemiology. (Print)
Numero volume della rivista37
Fascicolo della rivista5
Verificato da refereeSì: Internazionale
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)-
Parole chiaveNeuroblastoma, Time trend, Seasonality
Link (URL, URI)-
Titolo parallelo-
Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
Moduli/Attività/Sottoprogetti CNR-
Progetti Europei-
Full text (documento privato )
Tipo documento: application/pdf

Dati associati a vecchie tipologie
I dati associati a vecchie tipologie non sono modificabili, derivano dal cambiamento della tipologia di prodotto e hanno solo valore storico.
  • Elsevier, Amsterdam (Paesi Bassi)