Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloGuidelines for managing data and processes in bone and cartilage tissue engineering
Anno di pubblicazione2014
Autore/iViti, Federica; Scaglione, Silvia; Orro, Alessandro; Milanesi, Luciano
Affiliazioni autoriConsiglio Nazionale delle Ricerche (CNR); Consiglio Nazionale delle Ricerche (CNR)
Autori CNR e affiliazioni
AbstractBackground: In the last decades, a wide number of researchers/clinicians involved in tissue engineering field published several works about the possibility to induce a tissue regeneration guided by the use of biomaterials. To this aim, different scaffolds have been proposed, and their effectiveness tested through in vitro and/or in vivo experiments. In this context, integration and meta-analysis approaches are gaining importance for analyses and reuse of data as, for example, those concerning the bone and cartilage biomarkers, the biomolecular factors intervening in cell differentiation and growth, the morphology and the biomechanical performance of a neo-formed tissue, and, in general, the scaffolds' ability to promote tissue regeneration. Therefore standards and ontologies are becoming crucial, to provide a unifying knowledge framework for annotating data and supporting the semantic integration and the unambiguous interpretation of novel experimental results.
Lingua abstract-
Altro abstractResults: In this paper a conceptual framework has been designed for bone/cartilage tissue engineering domain, by now completely lacking standardized methods. A set of guidelines has been provided, defining the minimum information set necessary for describing an experimental study involved in bone and cartilage regenerative medicine field. In addition, a Bone/Cartilage Tissue Engineering Ontology (BCTEO) has been developed to provide a representation of the domain's concepts, specifically oriented to cells, and chemical composition, morphology, physical characterization of biomaterials involved in bone/cartilage tissue engineering research.
Lingua altro abstract-
Pagine da-
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Pagine totali12
RivistaBMC bioinformatics
Attiva dal 2000
Editore: BioMed Central, - [London]
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 1471-2105
Titolo chiave: BMC bioinformatics
Titolo proprio: BMC bioinformatics
Titolo abbreviato: BMC bioinformatics
Titoli alternativi:
  • BioMed Central bioinformatics
  • Bioinformatics
Numero volume della rivista15
Fascicolo della rivista-
Verificato da referee-
Stato della pubblicazione-
Indicizzazione (in banche dati controllate)
  • ISI Web of Science (WOS) (Codice:000330686700014)
Parole chiave-
Link (URL, URI)-
Titolo parallelo-
Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • IEIIT — IEIIT - Sede secondaria di Genova
  • ITB — Istituto di tecnologie biomediche
Moduli CNR
  • PB.P05.001.006 : Progetto Interomics- CdS 029
Progetti Europei-
Guidelines for managing data and processes in bone and cartilage tissue engineering (documento privato )
Tipo documento: application/pdf