Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloModulating human procedural learning by cerebellar transcranial direct current stimulation
Anno di pubblicazione2013
FormatoElettronico
Autore/iFerrucci R.; Brunoni A.R.; Parazzini M.; Vergari M.; Rossi E.; Fumagalli M.; Mameli F.; Rosa M.; Giannicola G.; Zago S.; Priori A.
Affiliazioni autoriCentro de Pesquisas Clínicas, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil; CNR Consiglio Nazionale Delle Ricerche, Istituto di Ingegneria Biomedica ISIB CNR, Milan, Italy; U.O. Neurofisiopatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; U.O. Neurologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Dipartimento di Fisiopatologia Medico-chirurgica e Dei Trapianti, Università Degli Studi di Milano, Milan, Italy
Autori CNR e affiliazioni
  • MARTA PARAZZINI
Lingua/e
  • inglese
AbstractNeuroimaging studies suggest that the cerebellum contributes to human cognitive processing, particularly procedural learning. This type of learning is often described as implicit learning and involves automatic, associative, and unintentional learning processes. Our aim was to investigate whether cerebellar transcranial direct current stimulation (tDCS) influences procedural learning as measured by the serial reaction time task (SRTT), in which subjects make speeded key press responses to visual cues. A preliminary modeling study demonstrated that our electrode montage (active electrode over the cerebellum with an extra-cephalic reference) generated the maximum electric field amplitude in the cerebellum. We enrolled 21 healthy subjects (aged 20-49 years). Participants did the SRTT, a visual analogue scale and a visual attention task, before and 35 min after receiving 20-min anodal and sham cerebellar tDCS in a randomized order. To avoid carry-over effects, experimental sessions were held at least 1 week apart. For our primary outcome measure (difference in RTs for random and repeated blocks) anodal versus sham tDCS, RTs were significantly slower for sham tDCS than for anodal cerebellar tDCS (p=0.04), demonstrating that anodal tDCS influenced implicit learning processes. When we assessed RTs for procedural learning across the one to eight blocks, we found that RTs changed significantly after anodal stimulation (interaction time×blocks 1/8: anodal, p=0.006), but after sham tDCS, they remained unchanged (p=0.094). No significant changes were found in the other variables assessed. Our finding that anodal cerebellar tDCS improves an implicit learning type essential to the development of several motor skills or cognitive activity suggests that the cerebellum has a critical role in procedural learning. tDCS could be a new tool for improving procedural learning in daily life in healthy subjects and for correcting abnormal learning in neuropsychiatric disorders.
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da485
Pagine a492
Pagine totali-
RivistaCerebellum (Lond., Online)
Attiva dal 2002
Editore: Springer - [London]
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 1473-4230
Titolo chiave: Cerebellum (Lond., Online)
Titolo proprio: The cerebellum (Lond., Online)
Titolo abbreviato: Cerebellum (Lond., Online)
Numero volume della rivista12
Fascicolo della rivista4
DOI10.1007/s12311-012-0436-9
Verificato da referee-
Stato della pubblicazione-
Indicizzazione (in banche dati controllate)
  • Scopus (Codice:2-s2.0-84892371317)
  • ISI Web of Science (WOS) (Codice:000321791100007)
Parole chiaveCerebellar transcranial direct current stimulation, Cerebellum, DC modeling, Human procedural learning, Serial reaction time task
Link (URL, URI)http://www.scopus.com/inward/record.url?eid=2-s2.0-84892371317&partnerID=q2rCbXpz
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Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
Moduli CNR-
Progetti Europei-
Allegati
Modulating human procedural learning by cerebellar transcranial direct current stimulation (documento privato )
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