Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloA regional blood flow model for glucose and insulin kinetics during hemodialysis
Anno di pubblicazione2013
Autore/iSchneditz D., Galach M., Thomaseth K., Waniewski J.
Affiliazioni autori1: Institute of Physiology, Medical University of Graz, Harrachgasse 21/5, 8010 Graz, Austria; 2,4: Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland; 3: Institute of Biomedical Engineering, Italian National Research Council, Padova, Italy
Autori CNR e affiliazioni
  • inglese
AbstractThe distribution and elimination of a bolus of glucose injected during hemodialysis (HD) was examined using a distributed double-pool regional blood flow model. Intracorporeal glucose disposal was assumed as insulin-independent (?) in the central high-flow compartment comprising blood, brain, and internal organs, including pancreatic insulin secretion (a, C1) and hepatic insulin clearance (?). Insulin-dependent (?) glucose utilization was allocated to the low-flow system comprising muscle, skin, and bone. This model was compared with a compact single-pool model using the same model parameters except for the distribution volume (V). Six parameters (C1, a, ?, ?, ?, and V) were identified from data obtained in seven nondiabetic patients (59-115 kg). The fraction Fd of glucose removed by HD significantly (p < 0.05) correlated with baseline glucose concentration Cg,0 (5.561
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da627
Pagine a635
Pagine totali-
RivistaASAIO journal (1992)
Attiva dal 1992
Editore: Published for the Society by J.B. Lippincott Co., - Hagerstown, MD
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1058-2916
Titolo chiave: ASAIO journal (1992)
Titolo proprio: ASAIO journal : (1992)
Titolo abbreviato: ASAIO j. (1992)
Titoli alternativi:
  • Peer reviewed journal of the American Society for Artificial Internal Organs (1992)
  • American Society for Artificial Internal Organs journal (1992)
Numero volume della rivista59
Fascicolo della rivista6
Verificato da refereeSì: Internazionale
Stato della pubblicazione-
Indicizzazione (in banche dati controllate)
  • Scopus (Codice:2-s2.0-84887255302)
Parole chiaveBlood flow modeling, Distribution volume, Extracorporeal systems, Fluid management, Glucose concentration, Insulin kinetics, Insulin secretion, Model parameters, Dialysis, Hemodialyzers, Hemodynamics, Insulin, Lakes, Glucose, glucose, insulin, adult, aged, article, blood flow, brain, clinical article, controlled study, diabetic patient, distribution volume, extracorporeal circulation, female, fluid therapy, glucose blood level, glucose transport, glucose utilization, hemodialysis, hemodialysis patient, human, insulin blood level, insulin clearance, insulin dependent diabetes mellitus, insulin release, liver, male, parameters, priority journal, systemic circulation, ultrafiltration
Link (URL, URI)
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Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
  • ISIB — Istituto di ingegneria biomedica
Moduli/Attività/Sottoprogetti CNR
  • ME.P06.016.001 : Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze
Progetti Europei-