Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloCats differ from other species in their cytokine and antioxidant enzyme response when developing obesity
Anno di pubblicazione2013
Formato-
Autore/iHoenig M., Pach N., Thomaseth K., Le A., Schaeffer D., Ferguson D.C.
Affiliazioni autori1,2: Department of Veterinary Clinical Medicine, University of Illinois, College of Veterinary Medicine, Urbana-Champaign, IL, United States; 3: Institute of Biomedical Engineering ISIB CNR, National Research Council of Italy, Padova, Italy; 4: Lipid Research Laboratory, Emory University School of Medicine, Atlanta VAMC, Atlanta, GA, United States; 5,6: Department of Comparative Biosciences, University of Illinois, College of Veterinary Medicine, Urbana-Champaign, IL, United States
Autori CNR e affiliazioni
  • KARL THOMASETH
Lingua/e
  • inglese
AbstractObjectives: Obese cats show many similarities to obese people, including insulin resistance and an increased diabetes risk. However, atherosclerosis and cardiovascular disease are not seen in cats. In people, they are associated with the development of an inflammatory response, which, we hypothesized, does not occur in cats. Design and Methods: Twenty neutered cats of equal gender distribution were allowed to gain weight by offering food ad libitum and were examined before and at 10, 30, 60, and 100% weight gain. All cats reached 60% of weight gain, 12 cats gained 100 % in 12 months. Results: Fat was equally distributed between subcutaneous and visceral depots. Insulin-independent glucose uptake increased and insulin sensitivity decreased with increasing adiposity. However, baseline glucose concentrations were unchanged suggesting a decrease in EGP. Inflammatory cytokines (Il-1, IL-6, TNFa) and catalase, superoxide dismutase, glutathione peroxidase did not change. Insulin, proinsulin, and leptin were positively and adiponectin negatively correlated with adiposity. Heat production increased with obesity, but became less when body weight gain was > 60 %. Conclusions: This indicates that metabolism adapts more appropriately to the higher intake of calories in the initial phase of obesity but slows at higher body fat content. This likely contributes to the difficulty to lose weight. Copyright
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da407
Pagine a414
Pagine totali-
RivistaObesity (Silver Spring, Md.)
Attiva dal 2006
Editore: Nature Pub. Group - Silver Spring, MD
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1930-7381
Titolo chiave: Obesity (Silver Spring, Md.)
Titolo proprio: Obesity. (Silver Spring, Md.)
Titolo alternativo: Obes. (Silver Spring, Md.)
Numero volume della rivista21
Fascicolo della rivista9
DOI10.1002/oby.20306
Verificato da refereeSì: Internazionale
Stato della pubblicazione-
Indicizzazione (in banche dati controllate)
  • Scopus (Codice:2-s2.0-84884902428)
Parole chiaveadiponectin, catalase, glutathione peroxidase, insulin, interleukin 1, interleukin 6, leptin, proinsulin, superoxide dismutase, tumor necrosis factor alpha, animal cell, animal experiment, animal tissue, article, concentration (parameters), controlled study, enzyme activity, experimental cat, fat mass, female, glucose transport, inflammation, insulin sensitivity, intravenous glucose tolerance test, lipid storage, longitudinal study, male, nonhuman, obesity, oxidative stress, sex ratio, species difference, thermogenesis, weight gain
Link (URL, URI)http://www.scopus.com/inward/record.url?eid=2-s2.0-84884902428&partnerID=40&md5=b7fadbb4248431e15b6e47037bedf382
Titolo parallelo-
Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
  • ISIB — Istituto di ingegneria biomedica
Moduli CNR
  • ME.P06.016.001 : Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze
Progetti Europei-
Allegati
Articolo pubblicato (documento privato )
Tipo documento: application/pdf