Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloSodium Concentration Measurement during Hemodialysis through Ion-Exchange Resin and Conductivity Measure Approach: In Vitro Experiments
Anno di pubblicazione2013
FormatoElettronico
Autore/iTura A., Sbrignadello S., Mambelli E., Ravazzani P., Santoro A., Pacini G.
Affiliazioni autoriTura A.: CNR Consiglio Nazionale delle Ricerche, Istituto di Ingegneria Biomedica ISIB Sbrignadello S.: CNR Consiglio Nazionale delle Ricerche, Istituto di Ingegneria Biomedica ISIB Mambelli E.: Nephrology Dialysis and Hypertension Unit, Policlinico S. Orsola-Malpighi, Bologna, Italy Ravazzani P.: CNR Consiglio Nazionale delle Ricerche, Istituto di Ingegneria Biomedica ISIB Santoro A.:Nephrology Dialysis and Hypertension Unit, Policlinico S. Orsola-Malpighi, Bologna, Italy Pacini G.: CNR Consiglio Nazionale delle Ricerche, Istituto di Ingegneria Biomedica ISIB
Autori CNR e affiliazioni
  • STEFANO SBRIGNADELLO
  • PAOLO GIUSEPPE RAVAZZANI
  • ANDREA TURA
  • GIOVANNI PACINI
Lingua/e
  • inglese
AbstractSodium measurement during hemodialysis treatment is important to preserve the patient from clinical events related to hypo- or hyper-natremia Usually, sodium measurement is performed through laboratory equipment which is typically expensive, and requires manual intervention. We propose a new method, based on conductivity measurement after treatment of dialysate solution through ion-exchange resin. To test this method, we performed in vitro experiments. We prepared 40 ml sodium chloride (NaCl) samples at 280, 140, 70, 35, 17.5, 8.75, 4.375 mEq/l, and some "mixed samples", i.e., with added potassium chloride (KCl) at different concentrations (4.375-17.5 mEq/l), to simulate the confounding factors in a conductivity-based sodium measurement. We measured the conductivity of all samples. Afterwards, each sample was treated for 1 min with 1 g of Dowex G-26 resin, and conductivity was measured again. On average, the difference in the conductivity between mixed samples and corresponding pure NaCl samples (at the same NaCl concentration) was 20.9%. After treatment with the exchange resin, it was 14.7%, i.e., 42% lower. Similar experiments were performed with calcium chloride and magnesium chloride as confounding factors, with similar results. We also performed some experiments on actual dialysate solution during hemodialysis sessions in 15 patients, and found that the correlation between conductivity measures and sodium concentration improved after resin treatment (R=0.839 before treatment, R=0.924 after treatment, P<0.0001). We conclude that ion-exchange resin treatment coupled with conductivity measures may improve the measurement of sodium compared to conductivity measures alone, and may become a possible simple approach for continuous and automatic sodium measurement during hemodialysis.
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da-
Pagine a-
Pagine totalie69227
RivistaPloS one
Attiva dal 2006
Editore: Public Library of Science - San Francisco, CA
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1932-6203
Titolo chiave: PloS one
Titolo proprio: PloS one
Titolo abbreviato: PLoS ONE
Titoli alternativi:
  • Public Library of Science one
  • PLoS 1
Numero volume della rivista8
Fascicolo della rivista7
DOI10.1371/journal.pone.0069227
Verificato da refereeSì: Internazionale
Stato della pubblicazione-
Indicizzazione (in banche dati controllate)
  • Scopus (Codice:2-s2.0-84879760935)
  • ISI Web of Science (WOS) (Codice:000321341000186)
Parole chiaveConductivity, Dialysis, Ion-exchange, Resin, Sodium, Ultrafiltration
Link (URL, URI)http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0069227
Titolo parallelo-
Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
  • ISIB — Istituto di ingegneria biomedica
  • IN — IN - Sede secondaria di Padova
Moduli CNR
    Progetti Europei-
    Allegati
    • PDF version of the paper