Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloRegulatory influence of scaffolds on cell behavior: how cells decode biomaterials
Anno di pubblicazione2011
Autore/iG. Pennesi, S. Scaglione, P. Giannoni, R. Quarto
Affiliazioni autoriUniversity of Genoa.
Autori CNR e affiliazioni
  • inglese
AbstractA stem cell is defined as a cell able to self-renew and at the same time to generate one or more specialized progenies. In the adult organism, stem cells need a specific microenvironment where to reside. This tissue-specific instructive microenvironment, hosting stem cells and governing their fate, is composed of extracellular matrix and soluble molecules. Cell-matrix and cell-cell interactions also contribute to the specifications of this milieu, regarded as a whole unitary system and referred to as "niche". For many stem cell systems a niche has been identified, but only partially defined. In regenerative medicine and tissue engineering, biomaterials are used to deliver stem cells in specific anatomical sites where a regenerative process is needed. In this context, biomaterials have to provide informative microenvironments mimicking a physiological niche. Stem cells may read and decode any biomaterial and modify their behavior and fate accordingly. Any material is therefore informative in the sense that its intrinsic nature and structure will anyway transmit a signal that will have to be decoded by colonizing cells. We still know very little of how to create local microenvironments, or artificial niches, that will govern stem cells behavior and their terminal fate. Here we will review some characteristics identifying specific niches and some of the requirements allowing stem cells differentiation processes. We will discuss on those biomaterials that are being projected/engineered/manufactured to gain the informative status necessary to drive proper molecular cross-talk and cell differentiation; specific examples will be proposed for bone and cartilage substitutes
Lingua abstractinglese
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RivistaCurrent pharmaceutical biotechnology (Online)
Attiva dal 2000
Editore: Bentham Science Publishers - Hilversum
Paese di pubblicazione: Paesi Bassi
Lingua: inglese
ISSN: 1873-4316
Titolo chiave: Current pharmaceutical biotechnology (Online)
Titolo proprio: Current pharmaceutical biotechnology. (Online)
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Stato della pubblicazionePublished version
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Parole chiaveBio-scaffold; Bone; Cartilage; Stem cell niche; Stem cells
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Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
Moduli CNR-
Progetti Europei-