Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloRestricted ROC curves are useful tools to evaluate the performance of tumour markers
Anno di pubblicazione2016
Autore/iS. Parodi, M. Muselli, B. Carlini, V. Fontana, R. Haupt, V. Pistoia, M.V. Corrias
Affiliazioni autoriS. Parodi, V. Fontana: IRCCS AOU San Martino-IST, Genoa, Italy; B. Carlini, R. Haupt, V. Pistoia, M.V. Corrias: G. Gaslini Children's Hospital, Genoa, Italy; M. Muselli: Institute of Electronics, Computer and Telecommunication Engineering, Genoa, Italy.
Autori CNR e affiliazioni
  • inglese
AbstractIn Clinical Epidemiology, receiver operating characteristic (ROC) analysis is a standard approach for the evaluation of the performance of diagnostic tests for binary classification based on a tumour marker distribution. The area under a ROC curve is a popular indicator of test accuracy, but its use has been questioned when the curve is asymmetric. This situation often happens when the marker concentrations overlap in the two groups under study in the range of low specificity, corresponding to a subset of values useless for classification purposes (non-informative values). The partial area under the curve at a high specificity threshold has been proposed as an alternative, but a method to identify an optimal cut-off that separates informative from non-informative values is not yet available. In this study, a new statistical approach is proposed to perform this task. Furthermore, a statistical test associated with the area under a ROC curve corresponding to informative values only (restricted ROC curve) is provided and its properties are explored by extensive simulations. Finally, the proposed method is applied to a real data set containing peripheral blood levels of six tumour markers proposed for the diagnosis of neuroblastoma. A new approach to combine couples of markers for classification purposes is also illustrated.
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da294
Pagine a313
Pagine totali20
RivistaStatistical methods in medical research
Attiva dal 1992
Editore: Edward Arnold. - Sevenoaks
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0962-2802
Titolo chiave: Statistical methods in medical research
Titolo abbreviato: Stat. methods med. res.
Numero volume della rivista25
Fascicolo della rivista1
Verificato da refereeSì: Internazionale
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • PubMed (Codice:22735161)
Parole chiaveTumour markers, receiver operating characteristic analysis, diagnostic tests, restricted receiver operating characteristic curve
Link (URL, URI)-
Titolo parallelo-
Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
Moduli/Attività/Sottoprogetti CNR
  • INT.P02.002.001 : Machine Learning for Biological Data
Progetti Europei-
Restricted ROC curves are useful tools to evaluate the performance of tumour markers (documento privato )
Tipo documento: application/pdf