Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloEvaluation of long-term glucose homeostasis in lean and obese cats by use of continuous glucose monitoring
Anno di pubblicazione2012
Formato-
Autore/iHoenig, M.;Pach, N.;Thomaseth, K.;Devries, F.;Ferguson, D.
Affiliazioni autoriFrom the Departments of Veterinary Clinical Medicine (Hoenig, Pach) and Comparative Bioscience (Ferguson), College of Veterinary Medicine, University of Illinois, Urbana-Champaign, IL 61802; Institute of Biomedical Engineering ISIB CNR - National Research Council of Italy, Corso Stati Uniti 4, 35127 Padova, Italy (Thomaseth); and Boehringer Ingelheim Vetmedica GmbH, Binger Strasse 173, 55216 Ingelheim am Rhein, Germany (de Vries).
Autori CNR e affiliazioni
  • KARL THOMASETH
Lingua/e-
AbstractObjective--To evaluate intraday and interday variations in glucose concentrations in cats and to test the utility of a continuous glucose monitoring system (CGMS). Animals--6 lean and 8 long-term (> 5 years) obese cats. Procedures--Blood glucose concentrations were measured during the course of 156 hours by use of a laboratory hexokinase-based reference method and a handheld glucometer. Interstitial glucose concentrations were evaluated with a CGMS. Results--Paired measures of glucose concentrations obtained with the CGMS typically were marginally higher than concentrations for the reference method and less biased than concentrations obtained with the glucometer. This was partially confirmed by the concordance correlation coefficients of the concentration for the CGMS or glucometer versus the concentration for the reference method, although the correlation coefficients were not significantly different. Mean ± SD area under the curve for the glucose concentration (AUCG) did not differ significantly between lean (14.0 ± 0.5 g/dLoh) and obese (15.2 + 0.5 g/dLoh) cats during the 156-hour period, but one of the obese cats had a much higher AUCG. Within-day glucose variability was small in both lean and obese cats. Conclusions and Clinical Relevance--Glucose homeostasis was maintained, even in long-term obese cats, and intraday glucose fluctuations were small. One obese cat might have been classified as prediabetic on the basis of the AUCG, which was approximately 25% higher than that of the other obese and lean cats. The CGMS can be useful in the evaluation of long-term effects of drugs or diet on glucose homeostasis in cats.
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da1100
Pagine a1106
Pagine totali-
RivistaAmerican journal of veterinary research
Attiva dal 1940
Editore: American Veterinary Medical Association - [Chicago]
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0002-9645
Titolo chiave: American journal of veterinary research
Titolo proprio: American journal of veterinary research.
Titolo abbreviato: Am. j. vet. res.
Titolo alternativo: AJVR
Numero volume della rivista73
Fascicolo della rivista7
DOI-
Verificato da referee-
Stato della pubblicazione-
Indicizzazione (in banche dati controllate)
  • Scopus (Codice:2-s2.0-84863438711)
  • ISI Web of Science (WOS) (Codice:000305669800025)
Parole chiave-
Link (URL, URI)http://www.ncbi.nlm.nih.gov/pubmed/22738065
Titolo parallelo-
Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
  • ISIB — Istituto di ingegneria biomedica
Moduli CNR
    Progetti Europei-
    Allegati
    • Evaluation of long-term glucose homeostasis in lean and obese cats by use of continuous glucose monitoring