Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloOrder versus Disorder: in vivo bone formation within osteoconductive scaffolds
Anno di pubblicazione2012
FormatoElettronico
Autore/iS. Scaglione; P. Giannoni; P. Bianchini; M. Sandri; R. Marotta; G. Firpo; U. Valbusa; A. Tampieri; A. Diaspro; P. Bianco; R. Quarto
Affiliazioni autoriAdvanced Biotechnology Center (CBA), Largo R. Benzi 10, 16145 Genoa, Italy IEIIT - Research National Council (CNR), Via De Marini 6, 16149 Genoa, Italy Italian Institute of Technology, Via Morego 30, 16100 Genoa, Italy ISTEC-CNR, Institute of Science and Technology for Ceramic Materials, National Research Institute, via Granarolo 64, 48018 Faenza, Italy Nanomed lab, Physics Department (DIFI), Via Dodecaneso, 33 16146 Genova and S.C. Nanobiotecnologie IST, Largo R. Benzi 10, 16132 Genoa, Italy Department of Molecular Medicine, Sapienza University of Rome, Viale regina Elena 324, 00161 Rome, Italy Department of Experimental Medicine (DIMES), University of Genoa, Largo R. Benzi 10, 16145 Genoa, Italy
Autori CNR e affiliazioni
  • MONICA SANDRI
  • SILVIA SCAGLIONE
  • ANNA TAMPIERI
Lingua/e
  • inglese
AbstractIn modern biomaterial design the generation of an environment mimicking some of the extracellular matrix features is envisaged to support molecular cross-talk between cells and scaffolds during tissue formation/remodeling. In bone substitutes chemical biomimesis has been particularly exploited; conversely, the relevance of pre-determined scaffold architecture for regenerated bone outputs is still unclear. Thus we aimed to demonstrate that a different organization of collagen fibers within newly formed bone under unloading conditions can be generated by differently architectured scaffolds. An ordered and confined geometry of hydroxyapatite foams concentrated collagen fibers within the pores, and triggered their self-assembly in a cholesteric-banded pattern, resulting in compact lamellar bone. Conversely, when progenitor cells were loaded onto nanofibrous collagen-based sponges, new collagen fibers were distributed in a nematic phase, resulting mostly in woven isotropic bone. Thus specific biomaterial design relevantly contributes to properly drive collagen fibers assembly to target bone regeneration.
Lingua abstractinglese
Altro abstract-
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Pagine da-
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Pagine totali6
RivistaScientific reports (Nature Publishing Group)
Attiva dal 2011
Editore: Nature Publishing Group - London
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 2045-2322
Titolo chiave: Scientific reports (Nature Publishing Group)
Titolo proprio: Scientific reports (Nature Publishing Group)
Numero volume della rivista2
Fascicolo della rivista-
DOI10.1038/srep00274
Verificato da referee-
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • ISI Web of Science (WOS) (Codice:000300585100002)
Parole chiavebiomaterials, tissue engineering
Link (URL, URI)http://www.nature.com/articles/srep00274
Titolo parallelo-
Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
  • ISTEC — Istituto di scienza e tecnologia dei materiali ceramici
Moduli CNR
    Progetti Europei-
    Allegati
    • Order versus Disorder: in vivo bone formation within osteoconductive scaffolds

    Dati associati a vecchie tipologie
    I dati associati a vecchie tipologie non sono modificabili, derivano dal cambiamento della tipologia di prodotto e hanno solo valore storico.
    Citazione bibliograficaScaglione, S. et al. Order versus Disorder: in vivo bone formation within osteoconductive scaffolds. Sci. Rep. 2, 274; DOI:10.1038/srep00274 (2012)