Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloModel-based assessment of insulin sensitivity of glucose disposal and endogenous glucose production from double-tracer oral glucose tolerance test
Anno di pubblicazione2008
Autore/iThomaseth K.; Pavan A.; Berria R.; Glass L.; Defronzo R.; Gastaldelli A.
Affiliazioni autori1, 2: CNR Institute of Biomedical Engineering, Padova, Italy; 3, 4, 5: University of Texas Health Science Center at San Antonio, USA; 6: CNR Institute of Clinical Physiology, Pisa, Italy
Autori CNR e affiliazioni
AbstractA new mathematical model of short-term glucose regulation by insulin is proposed to exploit the oral glucose tolerance test (OGTT), which is commonly used for clinical diagnosis of glucose intolerance and diabetes. Contributions of endogenous and exogenous sources to measured plasma glucose concentrations have been separated by means of additional oral administration and constant intravenous infusion of glucose labeled with two different tracers. Twelve type 2 diabetic patients (7 males and 5 females) and 10 control subjects (5 males and 5 females) with normal glucose tolerance and matched body mass index (BMI) participated in this study. Blood samples for measurement of concentrations/activity of unlabeled and double-tracer glucose and insulin were collected every 15 min for 3 h following the oral glucose load. A minimal model combined with non-linear mixed-effects population parameter estimation has been devised to characterize group-average and between-patient variability of: (i) gastrointestinal glucose absorption; (ii) endogenous glucose production (EGP), and (iii) glucose disposal rate. Results indicate that insulin-independent glucose clearance does not vary significantly with gender or diabetic state and that the latter strongly affects, as expected, insulin-dependent clearance (insulin sensitivity). Inhibition of EGP, interpreted in terms of variations from basal of insulin concentrations, does not appear to be affected by diabetes but rather by BMI, i.e. by the degree of obesity. This study supports the utility of a minimal modelling approach, combined with population parameter estimation, to characterize glucose absorption, production and disposition during double-tracer OGTT experiments. The model provides a means for planning further experiments to validate the new hypothesis on the influence of individual factors, such as BMI and diabetes, on glucose appearance and disappearance, and for designing new simplified clinical tests.
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Altro abstract-
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Pagine da132
Pagine a140
Pagine totali-
RivistaComputer methods and programs in biomedicine (Print)
Attiva dal 1985
Editore: Elsevier - London ;
Paese di pubblicazione: Paesi Bassi
Lingua: inglese
ISSN: 0169-2607
Titolo chiave: Computer methods and programs in biomedicine (Print)
Titolo proprio: Computer methods and programs in biomedicine. (Print)
Titolo abbreviato: Comput. methods programs biomed. (Print)
Numero volume della rivista89
Fascicolo della rivista-
Verificato da referee-
Stato della pubblicazione-
Indicizzazione (in banche dati controllate)
  • ISI Web of Science (WOS) (Codice:000253025500005)
  • Scopus (Codice:2-s2.0-37849044918)
Parole chiaveinsulin sensitivity, glucose tolerance
Link (URL, URI)
Titolo parallelo-
Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • IEIIT — Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni
  • IFC — Istituto di fisiologia clinica
  • ISIB — Istituto di ingegneria biomedica
Moduli/Attività/Sottoprogetti CNR
  • ME.P06.016.001 : Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze
Progetti Europei-
Model-based assessment of insulin sensitivity of glucose disposal and endogenous glucose production from double-tracer oral glucose tolerance test (documento privato )
Tipo documento: application/pdf

Dati storici
I dati storici non sono modificabili, sono stati ereditati da altri sistemi (es. Gestione Istituti, PUMA, ...) e hanno solo valore storico.
Area disciplinareMedical Research, General Topics
Area valutazione CIVRScienze mediche
NoteIn: Computer Methods and Programs in Biomedicine, vol. 89 (2) pp. 132 - 140. Elsevier Ireland Ltd, 2008.