@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS009 prodottidellaricerca:prodotto prodotto:ID9981 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA3721 pubblicazioni:autoreCNRDi prodotto:ID9981 . @prefix rdf: . prodotto:ID9981 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID9981 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID9981 rdfs:label "Pretreatment of rat brain synaptosomes with GABA increases subsequent GABA uptake via GABA(B) receptor activation. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID9981 pubblicazioni:anno "2001-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID9981 skos:altLabel "
Cupello A., Scarrone S. (2001)
Pretreatment of rat brain synaptosomes with GABA increases subsequent GABA uptake via GABA(B) receptor activation.
in Neurochemical research
"^^rdf:HTML ; pubblicazioni:autori "Cupello A., Scarrone S."^^xsd:string ; pubblicazioni:paginaInizio "11"^^xsd:string ; pubblicazioni:paginaFine "14"^^xsd:string ; pubblicazioni:numeroVolume "26"^^xsd:string . @prefix ns10: . prodotto:ID9981 pubblicazioni:rivista ns10:ID349843 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:titolo "Pretreatment of rat brain synaptosomes with GABA increases subsequent GABA uptake via GABA(B) receptor activation."^^xsd:string ; prodottidellaricerca:abstract "Pretreatment with 100 microM GABA of synaptosomes purified from rat brain results in an increased uptake of the labelled neurotransmitter in subsequent incubations. The effect is blocked by a GABA(B) receptor antagonist, 2-hydroxy-saclofen. The effect is mimicked by baclofen and the baclofen effect is blocked by saclofen too. Lower GABA concentrations (up to 50 microM) do not result in an increase of subsequent GABA uptake. Treatment of synaptosomes with 8-Br-cAMP results in a decreased GABA uptake. Since the uptake incubations were run with saturating concentrations of labelled GABA, the data indicates that GABA(B) receptor activation in brain synaptosomes up-regulates their GABA uptake capacity by an increase in Vmax. This mechanism appears of physiological relevance under conditions of sustained GABA release and substantial increase of its extracellular concentration.\n" ; prodottidellaricerca:prodottoDi istituto:CDS009 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA3721 . ns10:ID349843 pubblicazioni:rivistaDi prodotto:ID9981 .