@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA1631 pubblicazioni:autoreCNRDi prodotto:ID7196 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS003 prodottidellaricerca:prodotto prodotto:ID7196 . @prefix unitaDiPersonaleEsterno: . unitaDiPersonaleEsterno:ID3672 pubblicazioni:autoreCNRDi prodotto:ID7196 . @prefix modulo: . modulo:ID2707 prodottidellaricerca:prodotto prodotto:ID7196 . @prefix rdf: . @prefix retescientifica: . prodotto:ID7196 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID7196 rdfs:label "The relationship between plasma cholesterol, amino acids and acute phase proteins in sepsis (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID7196 pubblicazioni:anno "2004-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1007/s00726-004-0064-x"^^xsd:string . @prefix skos: . prodotto:ID7196 skos:altLabel "
Chiarla, C.; Giovannini, I.; Siegel, J.H. (2004)
The relationship between plasma cholesterol, amino acids and acute phase proteins in sepsis
in Amino acids (Wien, Print)
"^^rdf:HTML ; pubblicazioni:autori "Chiarla, C.; Giovannini, I.; Siegel, J.H."^^xsd:string ; pubblicazioni:paginaInizio "97"^^xsd:string ; pubblicazioni:paginaFine "100"^^xsd:string ; pubblicazioni:url "http://www.springerlink.com/content/mnjax3bh4dg5fc0k/fulltext.pdf"^^xsd:string ; pubblicazioni:numeroVolume "27"^^xsd:string . @prefix ns12: . prodotto:ID7196 pubblicazioni:rivista ns12:ID263297 ; pubblicazioni:pagineTotali "4"^^xsd:string ; pubblicazioni:numeroFascicolo "1"^^xsd:string ; skos:note "Scopu"^^xsd:string , "ISI Web of Science (WOS)"^^xsd:string , "PubMe"^^xsd:string ; pubblicazioni:affiliazioni "IASI-CNR Center for Pathophysiology of Shock, Department of Surgery, Hepatobiliary Unit, Surgical Intensive Care, Catholic University School of Medicine, Rome, Italy, and Department of Cell Biology and Molecular Medicine, UMDNJ, Newark, New Jersey, U.S.A."^^xsd:string ; pubblicazioni:titolo "The relationship between plasma cholesterol, amino acids and acute phase proteins in sepsis"^^xsd:string ; prodottidellaricerca:abstract "The purpose of the study was to correlate degree of hypocholesterolemia\nto changes in plasma levels of amino acids and other metabolic\nvariables in severely injured septic patients. Measurements included\nplasma cholesterol, full amino-acidograms, acute phase proteins, complementary\nvariables and blood cell counts. The Fischer plasma molar amino\nacid ratio (leucine+isoleucine+valine)/(phenylalanine+tyrosine) was\ncalculated. Plasma cholesterol for all measurements (n=145) was\n3.1+/- 1.1mmol/L and, upon entry in the study, it was correlated inversely\nwith sepsis severity score (p<0.05). Along the clinical course, changes in\ncholesterol were clearly paralleled by opposite changes in C-reactive\nprotein, which was the best correlate of cholesterol (r2=0.70, p<\n0.0001). Furthermore cholesterol was inversely related to phenylalanine,\nfibrinogen, lactate and white blood cell count, and directly to the\nFischer molar amino acid ratio, cystathionine, methionine, glycine and\ntransferrin (r2 between 0.36 and 0.15, p<0.0001 for all). Within this\npattern of correlations, cholesterol was also directly related to alkaline\nphosphatase, which accounted for the effect of cholestasis, when present.\nFor any given value of the other variables, cholesterol increased significantly\nwith increase in alkaline phosphatase (p<0.0001). C-reactive protein\n(CRP, mg/dl) and alkaline phosphatase (ALKPH, U/L) together\nin the same regression explained 79% of the variability of cholesterol\n(CHOL, mmol/L): CHOL=5.90-0.74[Log(e)CRP]+0.004[ALKPH];\nmultiple r2=0.79, p<0.0001. Inclusion in this regression of other variables\ndid not increase the r2. By using only amino acid variables, the best\nfit was provided by a regression including the Fischer ratio and cystathionine,\nwhich explained 55% of the variability of cholesterol (multiple\nr2=0.55 p<0.0001), and this result was not improved by the inclusion\nof other amino acids. These data show that severity of hypocholesterolemia\nin sepsis is quantifiably related to changes in plasma amino acids, and\nto severity of acute phase response and metabolic decompensation. More\nstudy is needed to understand whether hypocholesterolemia in sepsis has\nonly diagnostic or prognostic implications, or that it may also contribute\nactively to worsening of the disease."@en ; prodottidellaricerca:prodottoDi modulo:ID2707 , istituto:CDS003 ; pubblicazioni:autoreCNR unitaDiPersonaleEsterno:ID3672 , unitaDiPersonaleInterno:MATRICOLA1631 . @prefix parolechiave: . prodotto:ID7196 parolechiave:insiemeDiParoleChiave . ns12:ID263297 pubblicazioni:rivistaDi prodotto:ID7196 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID7196 .