@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA9854 pubblicazioni:autoreCNRDi prodotto:ID50209 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS081 prodottidellaricerca:prodotto prodotto:ID50209 . @prefix modulo: . modulo:ID2653 prodottidellaricerca:prodotto prodotto:ID50209 . @prefix rdf: . @prefix retescientifica: . prodotto:ID50209 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID50209 rdfs:label "Primary lateral sclerosis mimicking atypical parkinsonism. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID50209 pubblicazioni:anno "2007-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID50209 skos:altLabel "
Norlinah IM, Bhatia KP, Ostergaard K, Howard R, Arabia G, Quinn NP. (2007)
Primary lateral sclerosis mimicking atypical parkinsonism.
in Movement disorders
"^^rdf:HTML ; pubblicazioni:autori "Norlinah IM, Bhatia KP, Ostergaard K, Howard R, Arabia G, Quinn NP."^^xsd:string ; pubblicazioni:paginaInizio "2057"^^xsd:string ; pubblicazioni:paginaFine "2062"^^xsd:string ; pubblicazioni:numeroVolume "22(14"^^xsd:string . @prefix ns11: . prodotto:ID50209 pubblicazioni:rivista ns11:ID476734 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:titolo "Primary lateral sclerosis mimicking atypical parkinsonism."^^xsd:string ; prodottidellaricerca:abstract "Primary lateral sclerosis (PLS), the upper motor neurone variant of motor neurone disease, is characterized by progressive spinal or bulbar spasticity with minimal motor weakness. Rarely, PLS may present with clinical features resembling parkinsonism resulting in occasional misdiagnosis as one of the atypical parkinsonian syndromes. Here we describe five patients initially referred with a diagnosis of levodopa-unresponsive atypical parkinsonism (n = 4) or primary progressive multiple sclerosis (n = 1), but subsequently found to have features consistent with PLS instead. Onset age varied from 49 to 67 years. Unilateral limb slowness or clumsiness was the initial complaint in four, and bulbar symptoms in one. Repeated finger/foot tapping was slow in all five, but without fatiguing or decrement. Spasticity with hyperreflexia, exaggerated jaw jerk and extensor plantar responses were eventually seen in all patients. Anterior horn cell involvement developed in three cases. Early gait disturbances resulting in falls were seen in all patients and none of them responded to dopaminergic medications. Two patients underwent dopamine transporter (DaT) SPECT scanning with normal results. Other features included emotional lability (n = 5) and cognitive impairment involving frontal subcortical systems (n = 1). In conclusion, these cases represent a subgroup of PLS patients in whom pyramidal slowness may be mistaken for akinesia, and spasticity misconstrued as rigidity, leading to an erroneous diagnosis of atypical parkinsonism. However, the absence of fatiguing and decrement on repeated finger/foot tapping should help to distinguish these patients from the true atypical parkinsonian syndromes. (c) 2007 Movement Disorder Society.\n\n" ; prodottidellaricerca:prodottoDi modulo:ID2653 , istituto:CDS081 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA9854 . ns11:ID476734 pubblicazioni:rivistaDi prodotto:ID50209 .