@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS081 prodottidellaricerca:prodotto prodotto:ID50184 . @prefix modulo: . modulo:ID2703 prodottidellaricerca:prodotto prodotto:ID50184 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA9690 pubblicazioni:autoreCNRDi prodotto:ID50184 . @prefix rdf: . prodotto:ID50184 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID50184 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID50184 rdfs:label "Redox regulation in neurodegeneration and longevity: role of the heme oxygenase and HSP70 systems in brain stress tolerance (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID50184 pubblicazioni:anno "2004-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID50184 skos:altLabel "
Calabrese V, Stella AM, Butterfield DA, Scapagnini G. (2004)
Redox regulation in neurodegeneration and longevity: role of the heme oxygenase and HSP70 systems in brain stress tolerance
in Antioxidants & redox signalling
"^^rdf:HTML ; pubblicazioni:autori "Calabrese V, Stella AM, Butterfield DA, Scapagnini G."^^xsd:string ; pubblicazioni:paginaInizio "895"^^xsd:string ; pubblicazioni:paginaFine "913"^^xsd:string ; pubblicazioni:numeroVolume "6"^^xsd:string . @prefix ns11: . prodotto:ID50184 pubblicazioni:rivista ns11:ID167855 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Catania, Italy. calabres@mbox.unict.it"^^xsd:string ; pubblicazioni:titolo "Redox regulation in neurodegeneration and longevity: role of the heme oxygenase and HSP70 systems in brain stress tolerance"^^xsd:string ; prodottidellaricerca:abstract "Efficient functioning of maintenance and repair processes seems to be crucial for both survival and physical quality of life. This is accomplished by a complex network of the so-called longevity assurance processes, which are composed of several genes termed \\\"vitagenes,\\\" among these, the heat shock system, a highly conserved mechanism responsible for the preservation and repair of cellular macromolecules, such as proteins, RNAs, and DNA. Recent studies have shown that the heat shock response contributes to establishing a cytoprotective state in a wide variety of human diseases, including ischemia and reperfusion damage, inflammation, cancer, as well as metabolic and neurodegenerative disorders. Recently, the involvement of the heme oxygenase (HO) pathway in antidegenerative mechanisms has received considerable attention, as it has been demonstrated that the expression of HO is closely related to that of amyloid precursor protein. HO induction occurs together with the induction of other heat shock proteins during various physiopathological conditions. The vasoactive molecule carbon monoxide and the potent antioxidant bilirubin, products of HO-catalyzed reaction, represent a protective system potentially active against brain oxidative injury. Given the broad cytoprotective properties of the heat shock response, molecules inducing this defense mechanism appear to be possible candidates for novel cytoprotective strategies. Particularly, manipulation of endogenous cellular defense mechanisms, via the heat shock response, through nutritional antioxidants or pharmacological compounds, may represent an innovative approach to therapeutic intervention in diseases causing tissue damage, such as neurodegeneration. Consistently, by maintaining or recovering the activity of vitagenes, it is feasible to delay the aging process and decrease the occurrence of age-related diseases with resulting prolongation of a healthy life span.\n" ; prodottidellaricerca:prodottoDi istituto:CDS081 , modulo:ID2703 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA9690 . ns11:ID167855 pubblicazioni:rivistaDi prodotto:ID50184 .