@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS081 prodottidellaricerca:prodotto prodotto:ID49999 . @prefix modulo: . modulo:ID2653 prodottidellaricerca:prodotto prodotto:ID49999 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA9243 pubblicazioni:autoreCNRDi prodotto:ID49999 . @prefix rdf: . @prefix retescientifica: . prodotto:ID49999 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID49999 rdfs:label "Is language lateralization in temporal lobe epilepsy patients related to the nature of the epileptogenic lesion? (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID49999 pubblicazioni:anno "2006-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID49999 skos:altLabel "
Briellmann RS, Labate A, Harvey AS, Saling MM, Sveller C, Lillywhite L, Abbott DF, Jackson GD. (2006)
Is language lateralization in temporal lobe epilepsy patients related to the nature of the epileptogenic lesion?
in Epilepsia (Cph.)
"^^rdf:HTML ; pubblicazioni:autori "Briellmann RS, Labate A, Harvey AS, Saling MM, Sveller C, Lillywhite L, Abbott DF, Jackson GD."^^xsd:string ; pubblicazioni:paginaInizio "916"^^xsd:string ; pubblicazioni:paginaFine "920"^^xsd:string ; pubblicazioni:numeroVolume "47"^^xsd:string . @prefix ns11: . prodotto:ID49999 pubblicazioni:rivista ns11:ID381170 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:titolo "Is language lateralization in temporal lobe epilepsy patients related to the nature of the epileptogenic lesion?"^^xsd:string ; prodottidellaricerca:abstract "PURPOSE: Early acquired lesions are considered to be a risk factor for atypical language lateralization in epilepsy, whereas developmental lesions are not. Hippocampal sclerosis (HS) can be understood as an early, acquired lesion, whereas developmental tumors (DT) are thought to originate in utero. We assessed whether language lateralization differs between these groups of temporal lobe epilepsy patients. METHODS: We used 3-Tesla functional MRI (fMRI) to assess 41 patients (16 DT, 25 HS) and 50 controls, performing a noun-verb-generation task. fMRI data were processed by using SPM2. A laterality index (LI) was calculated based on the number of activated voxels in left- and right-sided frontal lobe language areas. Atypical lateralization was considered if the index was < or = 0.2. RESULTS: Patients had a lower LI (0.42 +/- 0.5) than controls (0.6 +/- 0.3; p < or = 0.05), but the LI was not different between DT (0.44 +/- 0.5) and HS patients (0.43 +/- 0.4; p = 0.9). The frequency of atypical lateralization was increased in patients (27%) compared with controls (8%) but was similar in both patient groups (DT, 31%; HS, 24%). HS patients had an earlier onset and longer duration of epilepsy and a higher frequency of significant antecedent events (p < or = 0.05). CONCLUSIONS: Patients with TLE demonstrate a deviation toward atypical language lateralization. However, language lateralization was not different between patients with presumably acquired lesions compared with patients with developmental pathology. This suggests that the nature of the temporal lobe lesion does not influence overall language lateralization.\n\n" ; prodottidellaricerca:prodottoDi modulo:ID2653 , istituto:CDS081 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA9243 . ns11:ID381170 pubblicazioni:rivistaDi prodotto:ID49999 .