@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS080 prodottidellaricerca:prodotto prodotto:ID49025 . @prefix modulo: . modulo:ID1946 prodottidellaricerca:prodotto prodotto:ID49025 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA5647 pubblicazioni:autoreCNRDi prodotto:ID49025 . @prefix rdf: . prodotto:ID49025 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID49025 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID49025 rdfs:label "Marine sponge-derived polymeric alkylpyridinium salts as a novel tumor chemotherapeutic targeting the cholinergic system in lung tumors (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID49025 pubblicazioni:anno "2006-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID49025 skos:altLabel "
Paleari L.; Tronbino S.; Falugi C.; Gallus L.; Carlone S.; Angelini C.; Sepcic K.; Turk T.; Faimali M.; Noonan D.M.; Albini A. (2006)
Marine sponge-derived polymeric alkylpyridinium salts as a novel tumor chemotherapeutic targeting the cholinergic system in lung tumors
in International journal of oncology
"^^rdf:HTML ; pubblicazioni:autori "Paleari L.; Tronbino S.; Falugi C.; Gallus L.; Carlone S.; Angelini C.; Sepcic K.; Turk T.; Faimali M.; Noonan D.M.; Albini A."^^xsd:string ; pubblicazioni:paginaInizio "1381"^^xsd:string ; pubblicazioni:paginaFine "1388"^^xsd:string ; pubblicazioni:url "http://www.spandidos-publications.com/ijo/29/6/1381"^^xsd:string ; pubblicazioni:numeroVolume "29"^^xsd:string . @prefix ns11: . prodotto:ID49025 pubblicazioni:rivista ns11:ID252755 ; pubblicazioni:numeroFascicolo "6"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string , "Scopu"^^xsd:string ; pubblicazioni:affiliazioni "(1) Laboratory of Molecular Oncology, Department of Translational Oncology, National Institute for Cancer Research (IST), Largo Rosanna Benzi 10, 16132 Genova, Italy \n(2) Laboratory of Developmental Biology, Department of Biology, University of Genoa, Genoa; \n(3) Biotechnical Faculty, Department of Biology, University of Ljubljana, Ljubljana, Slovenia \n(4) Marine Technology Section, Institute of Marine Sciences (ISMAR), National Research Council (CNR), Genoa\n(5) Department of Clinical and Biological Sciences, University of Insubria, Varese, Italy"^^xsd:string ; pubblicazioni:titolo "Marine sponge-derived polymeric alkylpyridinium salts as a novel tumor chemotherapeutic targeting the cholinergic system in lung tumors"^^xsd:string ; prodottidellaricerca:abstract "Previous studies have shown that the cholinergic system plays a pivotal rule in small cell lung cancer (SCLC) cell growth through an autocrine loop that activates the nicotinic cholinergic receptor, which together with the activation of this receptor by nicotine links SCLC evolution with tobacco use. \nNon-small cell lung cancer (NSCLC) is the most common form of lung cancer and is also linked to tobacco use. Here we describe the presence of molecules of the cholinergic system in NSCLC samples and cell lines and investigate the implications of the cholinergic system in cell growth regulation. Cholinoacetyltransferase (ChAT), vesicular acetylcholine transporter (VAChT) and acetylcholinesterase (AChE) were observed in NSCLC tumor biopsies and in NSCLC cell lines. Polymeric alkylpyridinium salts (poly-APS) are AChE inhibitors isolated from the crude extract of the marine sponge, Reniera sarai. These metabolites were characterized as a mixture of two polymers of 3-ctylpyridinium, including 29 and 99 monomeric units. Exposure of normal lung fibroblast and NSCLC cell lines to poly-APS revealed a selective cytotoxicity for cancer cells as compared to the normal fibroblast cell lines. FACS analysis indicated poly-APS induced apoptosis in NSCLC cells but not in normal lymphocytes. Non-toxic doses of poly-APS also potently reduced NSCLC cell-cell adhesion in suspension cultures. The limited toxicity of poly-APS on normal cells was confirmed by injection in the caudal vein of mice. No overt effects on health parameters, such as weight gain and physical behavior, were observed, and histological analysis of major organs did not reveal differences between the treated animals as compared to controls. These data demonstrate that NSCLC cells express cholinergic molecules that may be involved in cell growth regulation and that the cholinesterase inhibitor, poly-APS, shows selective toxicity toward NSCLC cells while having no apparent toxicity towards normal cells and tissue in vitro and in vivo."@en ; prodottidellaricerca:prodottoDi modulo:ID1946 , istituto:CDS080 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA5647 . @prefix parolechiave: . prodotto:ID49025 parolechiave:insiemeDiParoleChiave . ns11:ID252755 pubblicazioni:rivistaDi prodotto:ID49025 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID49025 .