@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS079 prodottidellaricerca:prodotto prodotto:ID48711 . istituto:CDS031 prodottidellaricerca:prodotto prodotto:ID48711 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA26 pubblicazioni:autoreCNRDi prodotto:ID48711 . unitaDiPersonaleInterno:MATRICOLA20145 pubblicazioni:autoreCNRDi prodotto:ID48711 . @prefix unitaDiPersonaleEsterno: . unitaDiPersonaleEsterno:ID7226 pubblicazioni:autoreCNRDi prodotto:ID48711 . @prefix modulo: . modulo:ID2029 prodottidellaricerca:prodotto prodotto:ID48711 . @prefix rdf: . prodotto:ID48711 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID48711 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID48711 rdfs:label "Urinary peptides as a diagnostic tool for renal failure detected by matrix-assisted laser desorption/ionisation mass spectrometry: an evaluation of their clinical significance (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID48711 pubblicazioni:anno "2011-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1255/ejms.1124"^^xsd:string . @prefix skos: . prodotto:ID48711 skos:altLabel "
Lapolla A.; Molin L.; Seraglia R.; Sechi A.; Cosma C.; Bonfante L.; Chilelli N.C.; Ragazzi E.; Traldi P. (2011)
Urinary peptides as a diagnostic tool for renal failure detected by matrix-assisted laser desorption/ionisation mass spectrometry: an evaluation of their clinical significance
in European journal of mass spectrometry
"^^rdf:HTML ; pubblicazioni:autori "Lapolla A.; Molin L.; Seraglia R.; Sechi A.; Cosma C.; Bonfante L.; Chilelli N.C.; Ragazzi E.; Traldi P."^^xsd:string ; pubblicazioni:paginaInizio "245"^^xsd:string ; pubblicazioni:paginaFine "253"^^xsd:string ; pubblicazioni:url "http://www.impublications.com/content/abstract?code=E17_0245"^^xsd:string ; pubblicazioni:numeroVolume "17"^^xsd:string . @prefix ns12: . prodotto:ID48711 pubblicazioni:rivista ns12:ID40428 ; pubblicazioni:descrizioneSinteticaDelProdotto "pubblicazione scientifica"^^xsd:string ; skos:note "Scopu"^^xsd:string , "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "1,4-7 : Department of Medical and Surgical Sciences, University of Padova, Via Giustiniani 2, I-35100 Padova, Italy /\n2,3,9 : CNR-ISTM, Corso Stati Uniti 4, I-35100 Padova, Italy /\n8 : Department of Pharmacology and Anesthesiology, University of Padova, Largo E. Meneghetti 2, I-35131 Padova, Italy"^^xsd:string ; pubblicazioni:titolo "Urinary peptides as a diagnostic tool for renal failure detected by matrix-assisted laser desorption/ionisation mass spectrometry: an evaluation of their clinical significance"^^xsd:string ; prodottidellaricerca:abstract "The development of new analytical methodologies related to the proteome for the evaluation of renal physiology and pathology is surely of wide interest for physicians, giving them new tools for monitoring complications associated with diabetes, such as end-stage renal disease. In the present study, the clinical significance of the urinary abundance of two peptides, SGSVIDQSRVLNLGPITR (the uromodulin precursor, m/z 1912) and IGPHypGPHypGLMGPP [present in the collagen-alpha-5(IV) chain precursor, m/z 1219], detected by matrix-assisted laser desorption/ionisation mass spectrometry (MALDI/MS) in microalbuminuric or nephropathic diabetic patients and in non-diabetic nephropathic patients was evaluated. A progressive increase in the abundance of the ion at m/z 1219 and a decrease in the abundance of the ion at m/z 1912 have been found in diabetic microalbuminuric, diabetic-nephropathic and nephropathic patients. Linear correlations are present between serum creatinine values and the abundances of the ions at m/z 1219 (positive correlation, r = 0.3645, P < 0.0001) and at m/z 1912 (negative correlation, r = -0.3053, P < 0.0005). Correlations between the MALDI data and the estimated glomerular filtration rate were also found, while relationships with urinary albumin excretion were found only in sub-sets of patients. Analysis of receiver operating characteristic curves showed a sensitivity up to 96% and a specificity of up to 84% for the two ionic species, or their ratio, for distinguishing diabetic patients with different degrees of nephropathy from healthy subjects, proving that the urinary abundance of the two peptides at m/z 1219 and m/z 1912, determined with MALDI/MS, may be considered as a possible diagnostic tool for the determination of progression toward renal failure, also with the aim of monitoring kidney function, in diabetic patients"@en ; prodottidellaricerca:prodottoDi istituto:CDS079 , modulo:ID2029 , istituto:CDS031 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA26 , unitaDiPersonaleEsterno:ID7226 , unitaDiPersonaleInterno:MATRICOLA20145 . @prefix parolechiave: . prodotto:ID48711 parolechiave:insiemeDiParoleChiave . ns12:ID40428 pubblicazioni:rivistaDi prodotto:ID48711 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID48711 .