@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS079 prodottidellaricerca:prodotto prodotto:ID48697 . istituto:CDS031 prodottidellaricerca:prodotto prodotto:ID48697 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA22251 pubblicazioni:autoreCNRDi prodotto:ID48697 . @prefix modulo: . modulo:ID6731 prodottidellaricerca:prodotto prodotto:ID48697 . @prefix rdf: . @prefix retescientifica: . prodotto:ID48697 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID48697 rdfs:label "Evaluation of 4-hydroxy-6-methyl-3-pyridinecarboxylic acid and 2,6-dimethyl-4-hydroxy-3-pyridinecarboxylic acid as chelating agents for iron and aluminium (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID48697 pubblicazioni:anno "2011-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID48697 skos:altLabel "
Dean A., Ferlin M.G., Brun P., Castagliuolo I., Yokel R.A., Venzo A., Bombi G.G., Di Marco V.B. (2011)
Evaluation of 4-hydroxy-6-methyl-3-pyridinecarboxylic acid and 2,6-dimethyl-4-hydroxy-3-pyridinecarboxylic acid as chelating agents for iron and aluminium
in Inorganica Chimica Acta (Testo stamp.)
"^^rdf:HTML ; pubblicazioni:autori "Dean A., Ferlin M.G., Brun P., Castagliuolo I., Yokel R.A., Venzo A., Bombi G.G., Di Marco V.B."^^xsd:string ; pubblicazioni:paginaInizio "179"^^xsd:string ; pubblicazioni:paginaFine "185"^^xsd:string ; pubblicazioni:altreInformazioni "doi: 10.1016/j.ica.2011.04.009"^^xsd:string ; pubblicazioni:numeroVolume "373"^^xsd:string . @prefix ns11: . prodotto:ID48697 pubblicazioni:rivista ns11:ID394634 ; pubblicazioni:descrizioneSinteticaDelProdotto "pubblicazione scientifica"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "Dipartimento di Scienze Chimiche, Universit\u00E0 di Padova, via Marzolo 1, 35131 Padova, Italy\nDipartimento di Scienze Farmaceutiche, Universit\u00E0 of Padova, via Marzolo 5, 35131 Padova, Italy\nDipartimento di Istologia, Microbiologia e Biotecnologie Mediche, via Gabelli 63, 35121 Padova, Italy\nPharmaceutical Sciences Department, 511C Multidisciplinary Science Building, University of Kentucky Academic Medical Center, Rose Street, Lexington, KY 40536-0082, USA\nCNR, Istituto di Scienze e Tecnologie Molecolari, via Marzolo 1, 35131 Padova, Italy"^^xsd:string ; pubblicazioni:titolo "Evaluation of 4-hydroxy-6-methyl-3-pyridinecarboxylic acid and 2,6-dimethyl-4-hydroxy-3-pyridinecarboxylic acid as chelating agents for iron and aluminium"^^xsd:string ; prodottidellaricerca:abstract "4-Hydroxy-6-methyl-3-pyridinecarboxylic acid (DQ6) and the new compound 2,6-dimethyl-4-hydroxy-3-pyridinecarboxylic acid (DQ726) were evaluated for possible application for iron (Fe) and aluminium (Al) chelation therapy. Metal/ligand solution chemistry, cytotoxicity, octanol/water partitioning (Do/w), and chelation efficiency were studied. The solution chemistry of the two ligands with Fe(III) and Al(III) was investigated in aqueous 0.6 m (Na)Cl at 25 \u00BAC by means of potentiometric titrations, UV\u0096Vis spectrophotometry, and 1H NMR spectroscopy. DQ6 exhibited a high coordination efficiency towards Al(III). Fe(III)/DQ6, Al(III)/DQ726, and Fe(III)/DQ726 complexes were less stable. These results were confirmed by chelation efficiency measurements performed in an octanol/aqueous solution. Accordingly, the effects of the substitution at various ring positions of 4-hydroxy-3-pyridinecarboxylic acid were rationalised. Partitioning experiments at pH 7.4 showed both DQ6 and DQ726, and their Fe(III) and Al(III) complexes, to be hydrophilic. The toxicity of DQ6 and of DQ726 was investigated with human cancer cell lines and normal human primary cells: no cytotoxic effects were observed up to 0.1 mM, following a 3 days exposure. According to our results, DQ6 has the favourable properties to be a chelating agent for Al." ; prodottidellaricerca:prodottoDi modulo:ID6731 , istituto:CDS031 , istituto:CDS079 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA22251 . ns11:ID394634 pubblicazioni:rivistaDi prodotto:ID48697 .