@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA42265 pubblicazioni:autoreCNRDi prodotto:ID46934 . unitaDiPersonaleInterno:MATRICOLA19655 pubblicazioni:autoreCNRDi prodotto:ID46934 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS078 prodottidellaricerca:prodotto prodotto:ID46934 . @prefix modulo: . modulo:ID2656 prodottidellaricerca:prodotto prodotto:ID46934 . @prefix rdf: . @prefix retescientifica: . prodotto:ID46934 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID46934 rdfs:label "Effects of EMDR psychotherapy on 99mTc-HMPAO distribution in occupation-related post-traumatic stress disorder (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID46934 pubblicazioni:anno "2007-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID46934 skos:altLabel "
Pagani M, H\u00F6gberg G, Salmaso D, Nardo D, T\u00E4rnell B, Jonsson C, Soares J, \u00C5berg-Wistedt A, Jacobsson H, H\u00E4llstr\u00F6m T, Larsson SA and Sundin O. (2007)
Effects of EMDR psychotherapy on 99mTc-HMPAO distribution in occupation-related post-traumatic stress disorder
in Nuclear medicine communications; Lippincott Williams &Wilkins, Hagerstown (Stati Uniti d'America)
"^^rdf:HTML ; pubblicazioni:autori "Pagani M, H\u00F6gberg G, Salmaso D, Nardo D, T\u00E4rnell B, Jonsson C, Soares J, \u00C5berg-Wistedt A, Jacobsson H, H\u00E4llstr\u00F6m T, Larsson SA and Sundin O."^^xsd:string ; pubblicazioni:paginaInizio "757"^^xsd:string ; pubblicazioni:paginaFine "765"^^xsd:string ; pubblicazioni:numeroVolume "27"^^xsd:string . @prefix ns11: . prodotto:ID46934 pubblicazioni:rivista ns11:ID415757 ; pubblicazioni:pagineTotali "9"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "Section of Nuclear Medicine and Department of Radiology, Karolinska University Hospital, Stockholm, Sweden; Institute of Cognitive Sciences and Technologies, CNR, Rome & Padua, Italy; Department of Clinical Neuroscience, Section for Psychiatry, Huddinge, Karolinska Institute, Stockholm, Sweden.\n4Hertie-Institute for Clinical Brain Research, Tuebingen, Germany\n5Section of Psychology, Department of Social Science, Mid Sweden University, \u00D6stersund, Sweden; Stockholm Centre of Public Health and Department of Public Health Sciences, Division of Social Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Neuroscience, Section of Psychology, Karolinska Institute, Stockholm, Sweden"^^xsd:string ; pubblicazioni:titolo "Effects of EMDR psychotherapy on 99mTc-HMPAO distribution in occupation-related post-traumatic stress disorder"^^xsd:string ; prodottidellaricerca:abstract "Background Post-traumatic stress disorder (PTSD) is a derangement of mood control with involuntary, emotionally fraught recollections that may follow deep psychological trauma in susceptible individuals. This condition is treated with pharmacological and/or cognitive therapies as well as psychotherapy with eye movement desensitization and reprocessing (EMDR). However, only a very limited number of studies have been published dealing with work-related PTSD, and investigations on the effect of treatment on cerebral blood flow represent an even smaller number.\n\nAim To investigate the short-term outcome of occupation-related PTSD after EMDR therapy by 99mTc-HMPAO SPECT.\n\nMethod Fifteen patients, either train drivers suffering from PTSD after having been unintentionally responsible of a person-under-train accident or employees assaulted in the course of duty, were recruited for the study. 99mTc-HMPAO SPECT was performed on these patients both before and after EMDR therapy while they listened to a script portraying the traumatic event. Tracer distribution analysis was then carried out at volume of interest (VOI) level using a 3D standardised brain atlas, and at cluster of voxel level by SPM. The CBF data were compared before and after treatment as well as with those of a group of 27 controls who had been exposed to the same psychological traumas without developing PTSD. \n\nResults At VOI analysis significant CBF distribution differences were found between controls and patients before and after treatment (p=0.023 and p=0.0039, respectively). Eleven of the fifteen patients responded to treatment, i.e. following EMDR they no longer fulfilled the DSM-IV criteria for PTSD. When comparing only the eleven responders with the controls, the significant group difference found before EMDR (p=0.019) disappeared after treatment. Responders and non-responders showed after therapy significant regional differences in frontal, parieto-occipital and visual cortex and in hippocampus. \nSPM analysis showed significant uptake differences between patients and controls in the orbitofrontal cortex (Brodmann 11) and the temporal pole (Brodmann 38) both before and after treatment. A significant tracer distribution difference present before treatment in the uncus (Brodmann 36) disappeared after treatment, while a significant difference appeared in the lateral temporal lobe (Brodmann 21). \n\nConclusion Significant 99mTc-HMPAO uptake regional differences were found, mainly in the peri-limbic cortex, between PTSD patients and controls exposed to trauma but not developing PTSD. Tracer uptake differences between responders and patients not responding to EMDR were found after treatment suggesting a trend towards normalisation of tracer distribution after successful therapy. These findings in occupational related PTSD are consistent with previously described effects of psychotherapy on anxiety disorders."@en . @prefix ns12: . prodotto:ID46934 pubblicazioni:editore ns12:ID12366 ; prodottidellaricerca:prodottoDi modulo:ID2656 , istituto:CDS078 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA19655 , unitaDiPersonaleInterno:MATRICOLA42265 . @prefix parolechiave: . prodotto:ID46934 parolechiave:insiemeDiParoleChiave . ns11:ID415757 pubblicazioni:rivistaDi prodotto:ID46934 . ns12:ID12366 pubblicazioni:editoreDi prodotto:ID46934 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID46934 .