@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA42265 pubblicazioni:autoreCNRDi prodotto:ID46725 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS078 prodottidellaricerca:prodotto prodotto:ID46725 . @prefix rdf: . prodotto:ID46725 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID46725 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID46725 rdfs:label "Alterations of rCBF and mitochondrial dysfunction in major depressive disorder: a case report. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID46725 pubblicazioni:anno "2003-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID46725 skos:altLabel "
Gardner A, Pagani M, Wibom R, Nennesmo I, Jacobsson H, H\u00E4llstr\u00F6m T. (2003)
Alterations of rCBF and mitochondrial dysfunction in major depressive disorder: a case report.
in Acta psychiatrica Scandinavica; Blackwell Munksgaard, Copenaghen (Danimarca)
"^^rdf:HTML ; pubblicazioni:autori "Gardner A, Pagani M, Wibom R, Nennesmo I, Jacobsson H, H\u00E4llstr\u00F6m T."^^xsd:string ; pubblicazioni:paginaInizio "233"^^xsd:string ; pubblicazioni:paginaFine "239"^^xsd:string ; pubblicazioni:numeroVolume "107"^^xsd:string . @prefix ns10: . prodotto:ID46725 pubblicazioni:rivista ns10:ID392360 ; pubblicazioni:pagineTotali "7"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "NEUROTEC Department, Division of Psychiatry, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden,\nSection of Nuclear Medicine, Department of Hospital Physics, Karolinska Hospital, Stockholm, Sweden,\nInstitute of Neurobiology and Molecular Medicine, CNR, Rome, Italy,\nCentre for Inherited Metabolic Diseases, Huddinge University Hospital, Stockholm, Sweden, \nDivision of Pathology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden and\nDepartment of Diagnostic Radiology, Karolinska Hospital, Stockholm, Sweden"^^xsd:string ; pubblicazioni:titolo "Alterations of rCBF and mitochondrial dysfunction in major depressive disorder: a case report."^^xsd:string ; prodottidellaricerca:abstract "Background. A mitochondrial disease might be considered when depressive disorder is associated with diabetes mellitus or other symptoms commonly found in mitochondrial disease. Scattered rCBF decreases and increases have been reported in depressive and mitochondrial disorders.\nMethod. A 61-year old male patient with early adult onset of depressive disorder and a slowly developing multiorgan syndrome including diabetes mellitus was investigated with 99mTc-HMPAO rCBF SPECT, and muscle biopsy to assess mitochondrial functions.\nResults. Alterations of rCBF were found in the patient, with the most pronounced decreases in the left dorsolateral frontal and inferior parietal lobes, and the most pronounced increases in the bilateral superior parietal lobe. Muscle biopsy revealed myopathy and decrease of mitochondrial ATP production rates (MAPRs).\nConclusion. The MAPRs decreases support the suspicion of mitochondrial dysfunction in the patient. A subgroup of depressed patients may have mitochondrial dysfunctions."@en . @prefix ns11: . prodotto:ID46725 pubblicazioni:editore ns11:ID12119 ; prodottidellaricerca:prodottoDi istituto:CDS078 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA42265 . ns10:ID392360 pubblicazioni:rivistaDi prodotto:ID46725 . ns11:ID12119 pubblicazioni:editoreDi prodotto:ID46725 .