@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA45002 pubblicazioni:autoreCNRDi prodotto:ID4671 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS059 prodottidellaricerca:prodotto prodotto:ID4671 . unitaDiPersonaleInterno:MATRICOLA3516 pubblicazioni:autoreCNRDi prodotto:ID4671 . @prefix unitaDiPersonaleEsterno: . unitaDiPersonaleEsterno:ID4277 pubblicazioni:autoreCNRDi prodotto:ID4671 . @prefix modulo: . modulo:ID2651 prodottidellaricerca:prodotto prodotto:ID4671 . unitaDiPersonaleInterno:MATRICOLA15719 pubblicazioni:autoreCNRDi prodotto:ID4671 . @prefix rdf: . prodotto:ID4671 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID4671 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID4671 rdfs:label "Expression of NK-1 and NK-3 tachykinin receptors in pancreatic acinar cells after acute experimental pancreatitis in rats. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID4671 pubblicazioni:anno "2006-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID4671 skos:altLabel "
Broccardo M.1, Linari G.2, Agostini S.3, Amadoro G.4, Carpino F.5, Ciotti M.T.6, Petrella C.7, Petrozza V.8, Severini C.9, Improta G.10 (2006)
Expression of NK-1 and NK-3 tachykinin receptors in pancreatic acinar cells after acute experimental pancreatitis in rats.
in American journal of physiology: Gastrointestinal and liver physiology
"^^rdf:HTML ; pubblicazioni:autori "Broccardo M.1, Linari G.2, Agostini S.3, Amadoro G.4, Carpino F.5, Ciotti M.T.6, Petrella C.7, Petrozza V.8, Severini C.9, Improta G.10"^^xsd:string ; pubblicazioni:paginaInizio "G518"^^xsd:string ; pubblicazioni:paginaFine "G524"^^xsd:string ; pubblicazioni:numeroVolume "291/3"^^xsd:string . @prefix ns12: . prodotto:ID4671 pubblicazioni:rivista ns12:ID416775 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "1,2,3,7,10 = Department of Human Physiology and Pharmacology, V. Erspamer; \nand 5,8 = Department of Experimental Medicine and Biopathology, University of Rome, La Sapienza;\n4,6,9 = Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy."^^xsd:string ; pubblicazioni:titolo "Expression of NK-1 and NK-3 tachykinin receptors in pancreatic acinar cells after acute experimental pancreatitis in rats."^^xsd:string ; prodottidellaricerca:abstract "Activation of neurokinin (NK)-1 receptors but not of NK-3 stimulates amylase release from isolated pancreatic acini of the rat. Immunofluorescence studies show that NK-1 receptors are more strongly expressed than NK-3 receptors on pancreatic acinar cells under basal conditions. No studies have examined the expression of the two NK receptor populations in pancreatic acini during pancreatitis in rats. We therefore investigated the relationships between expression of these two tachykinin receptors and experimental acute pancreatitis induced by stimulating pancreatic amylase with caerulein (CK) in rats. Hyperstimulation of the pancreas by CK caused an increase in plasma amylase and pancreatic water content and resulted in morphological evidence of cytoplasmic vacuolization. Immunofluorescence analysis revealed a similar percentage of NK-1 receptor antibody immunoreactive acinar cells in rats with pancreatitis and in normal rat tissue but a larger percentage of NK-3 receptor immunoreactive cells in acute pancreatitis than in normal pancreas. Western blot analysis of NK-1 and NK-3 receptor protein levels after CK-induced pancreatitis showed no change in NK-1 receptors but a stronger increase in NK-3 receptor expression in pancreatic acini compared with normal rats thus confirming the immunofluorescence data. These new findings support previous evidence that substance P-mediated functions within the pancreas go beyond sensory signal transduction contributing to neurogenic inflammation, and they suggest that substance P plays a role in regulating pancreatic exocrine secretion via acinar NK-1 receptors. The significant increase in NK-3 receptors during pancreatic stimulation suggests that NK-3 receptors also intervene in the pathogenesis of mild acute pancreatitis in rats." ; prodottidellaricerca:prodottoDi modulo:ID2651 , istituto:CDS059 ; pubblicazioni:autoreCNR unitaDiPersonaleEsterno:ID4277 , unitaDiPersonaleInterno:MATRICOLA3516 , unitaDiPersonaleInterno:MATRICOLA45002 , unitaDiPersonaleInterno:MATRICOLA15719 . ns12:ID416775 pubblicazioni:rivistaDi prodotto:ID4671 .