@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA42265 pubblicazioni:autoreCNRDi prodotto:ID46701 . unitaDiPersonaleInterno:MATRICOLA19655 pubblicazioni:autoreCNRDi prodotto:ID46701 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS078 prodottidellaricerca:prodotto prodotto:ID46701 . @prefix modulo: . modulo:ID2656 prodottidellaricerca:prodotto prodotto:ID46701 . @prefix rdf: . prodotto:ID46701 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID46701 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID46701 rdfs:label "Value of Nucleus Caudatus and Thalamus SPECT rCBF in discriminating among Alzheimer Disease, Unipolar Depression and normal individuals (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID46701 pubblicazioni:anno "2002-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID46701 skos:altLabel "
Pagani M., Gardner A., Salmaso D., Sanchez-Crespo A., Jonsson C., Ramstrom C., Wagner A., Jacobsson H., Larsson S.A.. (2002)
Value of Nucleus Caudatus and Thalamus SPECT rCBF in discriminating among Alzheimer Disease, Unipolar Depression and normal individuals
in European journal of nuclear medicine and molecular imaging (Print)
"^^rdf:HTML ; pubblicazioni:autori "Pagani M., Gardner A., Salmaso D., Sanchez-Crespo A., Jonsson C., Ramstrom C., Wagner A., Jacobsson H., Larsson S.A.."^^xsd:string ; pubblicazioni:paginaInizio "s134"^^xsd:string ; pubblicazioni:numeroVolume "29"^^xsd:string . @prefix ns11: . prodotto:ID46701 pubblicazioni:rivista ns11:ID69266 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "Institute of Cognitive Sciences and Technologies, CNR, Rome, Italy"^^xsd:string ; pubblicazioni:titolo "Value of Nucleus Caudatus and Thalamus SPECT rCBF in discriminating among Alzheimer Disease, Unipolar Depression and normal individuals"^^xsd:string ; prodottidellaricerca:abstract "Background: Basal ganglia and thalamus play a central role, via the\ncortico-basal ganglia-thalamus-cortical loop, in the processing of the\nneuronal signal from and to the cerebral cortex. Metabolic alterations in\nthe neocortex, causing proportional regional cerebral blood flow (rCBF)\nchanges, affect neuronal signal also in such structures. The aim of this\nstudy was to investigate the possibility of using the rCBF of the central\nstructures in discriminating Alzheimer Disease (AD) and Unipolar Depression\n(UNI) patients from normal controls (CTR).\nMethods: 47 AD patients, 70 UNI patients and 66 CTR were included in the\nstudy. rCBF was assessed by 99m-Tc-HMPAO and using a three-headed gamma\ncamera. A standardised brain atlas was used to define volumes of interest\ncorresponding to nc. caudatus, putamen and thalamus. Analysis of variance\n(ANOVA) was used to test the significance of the differences in flow and\ndata were covariated for age. Receiver Operating Characteristic (ROC)\ncurves were implemented to evaluate the ability of the rCBF in the\ndifferent structures to discriminate between the groups. \nResults: ANOVA showed a significant overall rCBF group difference\n(p<0.001). As compared to CTR, rCBF in nc. caudatus and thalamus decreased\nin AD and increased in UNI. The blood flow in putamen was significantly\nincreased only in the CTR/UNI comparison (p<0.001). Thalamus blood flow\nsignificantly differed in the CTR/AD (p<0.02) and CTR/UNI (p< 0.001)\ncomparisons. Nc. caudatus blood flow significantly discriminated all three\ngroups (CTR/AD:p<0.001; CTR/UNI: p<0.001; AD/UNI:p<0.01). According to ROC\ncurves, nc. caudatus correctly categorised 74% of the individuals in the\nCTR-AD group pair and 72% in the CRT-UNI group pair.\nConclusions: The blood flow in nc. caudatus and thalamus reflected\ncorresponding changes in cortical regions in both AD and UNI. The decreased\nperfusion in the temporo-parietal cortex of the AD patients and the\nincreased blood flow in the fronto-temporal cortex of the UNI patients were\nconcomitant in nc. caudatus and thalamus. This is consistent with the\nanatomical path of the cortico-basal ganglia-thalamus-cortical loop\nprojecting the fronto-temporo-parietal association cortex fibres in a\nsegregated manner to nc. caudatus and thalamus. The putamen receives fibres\nmainly from motor and pre-motor cortices not involved in AD." ; prodottidellaricerca:prodottoDi istituto:CDS078 , modulo:ID2656 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA42265 , unitaDiPersonaleInterno:MATRICOLA19655 . ns11:ID69266 pubblicazioni:rivistaDi prodotto:ID46701 .