@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS076 prodottidellaricerca:prodotto prodotto:ID45669 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA507 pubblicazioni:autoreCNRDi prodotto:ID45669 . @prefix modulo: . modulo:ID8466 prodottidellaricerca:prodotto prodotto:ID45669 . @prefix rdf: . @prefix retescientifica: . prodotto:ID45669 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID45669 rdfs:label "Fish oil, insulin sensitivity, insulin secretion and glucose tolerance in healthy people: is there any effect of fish oil supplementation in relation to the type of background diet and habitual dietary intake of n-6 and n-3 fatty acids? (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID45669 pubblicazioni:anno "2007-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1016/j.numecd.2006.06.006"^^xsd:string . @prefix skos: . prodotto:ID45669 skos:altLabel "
Giacco R; Cuomo V; Vessby B; Uusitupa M; Hermansen K; Meyer B J; Riccardi G; Rivellese A A. (2007)
Fish oil, insulin sensitivity, insulin secretion and glucose tolerance in healthy people: is there any effect of fish oil supplementation in relation to the type of background diet and habitual dietary intake of n-6 and n-3 fatty acids?
in NMCD. Nutrition Metabolism and Cardiovascular Diseases (Testo stamp.); Medikal Press, Milano (Italia)
"^^rdf:HTML ; pubblicazioni:autori "Giacco R; Cuomo V; Vessby B; Uusitupa M; Hermansen K; Meyer B J; Riccardi G; Rivellese A A."^^xsd:string ; pubblicazioni:paginaInizio "572"^^xsd:string ; pubblicazioni:paginaFine "580"^^xsd:string ; pubblicazioni:altreInformazioni "4"^^xsd:string ; pubblicazioni:numeroVolume "17"^^xsd:string . @prefix ns11: . prodotto:ID45669 pubblicazioni:rivista ns11:ID263298 ; skos:note "PubMe"^^xsd:string , "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "Institute of Food Science, Italian National Research Council, Via Roma 52 A/C, 83100 Avellino, Italy\nDepartment of Clinical and Experimental Medicine, School of Medicine, Federico II University, Naples, Italy\nUnit for Clinical Nutrition Research, Department of Public Health and Caring Sciences/Geriatrics, University of Uppsala, Uppsala, Sweden\nDepartment of Clinical Nutrition, University of Kuopio, Kuopia, Finland\nDepartment of Clinical Endocrinology and Metabolism, Aarhus University Hospital, Aarhus, Denmark\nDepartment of Biomedical Sciences and Metabolic Research Centre, University of Wollongong, Wollongong, Australia"^^xsd:string ; pubblicazioni:titolo "Fish oil, insulin sensitivity, insulin secretion and glucose tolerance in healthy people: is there any effect of fish oil supplementation in relation to the type of background diet and habitual dietary intake of n-6 and n-3 fatty acids?"^^xsd:string ; prodottidellaricerca:abstract "To evaluate whether a moderate supplementation of long-chain n-3 fatty acids is able to modulate insulin sensitivity, insulin secretion, beta-cell function and glucose tolerance in healthy individuals consuming a diet rich in either saturated or monounsaturated fat, also in relation to their habitual dietary intake of n-6 and n-3 fatty acid. METHODS AND RESULTS: One hundred and sixty-two healthy individuals were randomly assigned to follow either one of two isoenergetic diets for 3months, one rich in monounsaturated fats and the other rich in saturated fats. Within each group there was a second randomisation to fish oil (n-3 fatty acids 3.6g/day) or placebo. At the beginning and at the end of the treatment periods insulin sensitivity (SI), first phase insulin response (FPIR) and glucose tolerance (K(G)-value) were evaluated by the intravenous glucose tolerance test (IVGTT). Fish oil did not have any effect on SI, FPIR, K(G)-value and disposition index in either diet. Even after dividing subjects according to the median value of n-6/n-3 ratio of serum phospholipids at baseline, there was no change in SI (Delta SI 0.42+/-0.34 on fish oil vs 0.14+/-0.23 on placebo for those with n-6/n-3 <4.85; -1.03+/-0.47 on fish oil vs -0.27+/-0.32 on placebo for those with n-6/n-3 >4.85) (M+/-SE), FPIR (Delta FPIR 135.9+/-78.9 vs 157.2+/-157.5pmol/L; 38.8+/-181.7 vs 357.1+/-181.7pmol/L), K(G)-value (Delta K(G) 0.14+/-0.15 vs 0.12+/-0.11; -0.32+/-0.16 vs 0.15+/-0.15) or disposition index (Delta disposition index 1465.4+/-830.4 vs 953.8+/-690.0; -1641.6+/-1034.3 vs 446.6+/-905.1). Considering the 75th percentile of n-6/n-3 ratio (5.82) the results on insulin sensitivity, insulin secretion and disposition index were confirmed, while, in this more extreme situation, n-3 fatty acid supplementation induced a significant deterioration of K(G)-value (p=0.02). CONCLUSIONS: In healthy individuals a moderate supplementation of fish oil does not affect insulin sensitivity, insulin secretion, beta-cell function or glucose tolerance. The same is true even when the habitual dietary intake of n-6 and n-3 fatty acids is taken into account."@en . @prefix ns12: . prodotto:ID45669 pubblicazioni:editore ns12:ID8136 ; prodottidellaricerca:prodottoDi istituto:CDS076 , modulo:ID8466 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA507 . @prefix parolechiave: . prodotto:ID45669 parolechiave:insiemeDiParoleChiave . ns11:ID263298 pubblicazioni:rivistaDi prodotto:ID45669 . ns12:ID8136 pubblicazioni:editoreDi prodotto:ID45669 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID45669 .