@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS076 prodottidellaricerca:prodotto prodotto:ID45611 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA719 pubblicazioni:autoreCNRDi prodotto:ID45611 . unitaDiPersonaleInterno:MATRICOLA687 pubblicazioni:autoreCNRDi prodotto:ID45611 . unitaDiPersonaleInterno:MATRICOLA718 pubblicazioni:autoreCNRDi prodotto:ID45611 . unitaDiPersonaleInterno:MATRICOLA30 pubblicazioni:autoreCNRDi prodotto:ID45611 . unitaDiPersonaleInterno:MATRICOLA507 pubblicazioni:autoreCNRDi prodotto:ID45611 . @prefix unitaDiPersonaleEsterno: . unitaDiPersonaleEsterno:ID4789 pubblicazioni:autoreCNRDi prodotto:ID45611 . @prefix modulo: . modulo:ID8466 prodottidellaricerca:prodotto prodotto:ID45611 . @prefix rdf: . prodotto:ID45611 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID45611 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID45611 rdfs:label "Effects of fructo-oligosaccarides on glucose and lipid metabolism in mild hypercholesterolemic individuals. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID45611 pubblicazioni:anno "2004-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1016/j.clnu.2003.07.010"^^xsd:string . @prefix skos: . prodotto:ID45611 skos:altLabel "
Giacco R; Clemente G; Luongo D; F.Bornet F; Brouns F; Patti L; Lasorella G; Fiume I; Cipriano P; Rivellese AA; Riccardi G (2004)
Effects of fructo-oligosaccarides on glucose and lipid metabolism in mild hypercholesterolemic individuals.
in Clinical nutrition (Edinb.)
"^^rdf:HTML ; pubblicazioni:autori "Giacco R; Clemente G; Luongo D; F.Bornet F; Brouns F; Patti L; Lasorella G; Fiume I; Cipriano P; Rivellese AA; Riccardi G"^^xsd:string ; pubblicazioni:paginaInizio "331"^^xsd:string ; pubblicazioni:paginaFine "340"^^xsd:string ; pubblicazioni:altreInformazioni "6"^^xsd:string ; pubblicazioni:numeroVolume "23"^^xsd:string . @prefix ns12: . prodotto:ID45611 pubblicazioni:rivista ns12:ID434652 ; pubblicazioni:numeroFascicolo "3"^^xsd:string ; skos:note "PubMe"^^xsd:string , "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "Institute of Food Science and Technology of National Research Council, Avellino, Italy\nCerestar Research & Development Center, Vilvoorde, Belgium\nNutri-Health, Rueil-Malmaison, France\nDepartment of Clinical and Experimental Medicine, Medical School of University \\\"Federico II\\\" Naples, Italy"^^xsd:string ; pubblicazioni:titolo "Effects of fructo-oligosaccarides on glucose and lipid metabolism in mild hypercholesterolemic individuals."^^xsd:string ; prodottidellaricerca:abstract "BACKGROUND: The intake of 10 g/day of short-chain-fructo-oligosaccharides (sc-FOS) has been shown to increase significantly bifidus counts and to produce high amounts of short-chain fatty acids (SCFA), presumed to influence glucose and lipid metabolism. AIM: To evaluate the effects of moderate intake of sc-FOS on glucose and lipid metabolism in individuals with mild hypercholesterolaemia. Design: A randomized double-blind sequential cross-over study. SUBJECTS AND METHODS: Thirty subjects of both genders (20 M/10 F), mean age 45.5+/-9.9 years (M+/-SD), BMI 26.6+/-2.2 kg/m(2), with plasma cholesterol >5.17 and <7.76 mmol/l and plasma triglycerides <3.45 mmol/l, participated in the study. The study was performed after a wash-out period of 1 month and a run-in period of 1 month to stabilize patients on a standard diet (CHO 50%, fat 30%, protein 20%, fibre 20 g/day) plus placebo (maltodextrine plus aspartame 15 g/day). At the end of run-in, subjects were randomly assigned to receive sc-FOS (Actilight) (10.6g/day) or placebo (maltodextrine plus aspartame 15 g/day) with tea and/or coffee for a duration of 2 months and thereafter switched to the other treatment for additional 2 months. Plasma glucose, total and lipoprotein (VLDL, LDL, HDL) cholesterol and triglyceride concentrations were measured in the fasting state at the end of run-in and of each treatment period. At the end of the two treatment periods, patients consumed a standard test meal (protein 15%, carbohydrate 34%, fat 51%, kJ 3988) 1h after the administration of 5.3g of sc-FOS or placebo; plasma glucose, insulin, free fatty acid (FFA) and triglyceride responses to the test meal were evaluated. RESULTS: No significant difference in fasting parameters was detected between the two treatments. After sc-FOS and placebo plasma cholesterol levels were, respectively, 6.47+/-0.70 and 6.44+/-0.78 mmol/l (n.s.) and plasma triglycerides were 1.53+/-0.71 and 1.56+/-0.53 mmol/l (n.s.). No significant differences were observed in cholesterol and triglyceride content of VLDL, LDL and HDL and in plasma Apo A1 levels; conversely, fasting plasma Lp(a) concentrations were significantly increased after sc-FOS (37+/-38 vs. 33+/-35 mg/dl; P<0.005). Postprandial responses of glucose, FFA and triglycerides were not significantly different between sc-FOS and placebo, while postprandial insulin response (incremental area) was significantly reduced after sc-FOS compared to placebo (14,490+/-7416 vs. 17,760+/-7710 pmol/l x 300 min; P<0.02). CONCLUSIONS: A moderate intake of sc-FOS has no major effects on lipid metabolism, both in the fasting and in the postprandial period, in individuals with mild hypercholesterolaemia. A small but significant increase of Lp(a) concentrations was observed with sc-FOS consumption together with a reduction of the postprandial insulin response; however, the clinical relevance of these small effects is unclear."@en ; prodottidellaricerca:prodottoDi istituto:CDS076 , modulo:ID8466 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA30 , unitaDiPersonaleInterno:MATRICOLA687 , unitaDiPersonaleInterno:MATRICOLA719 , unitaDiPersonaleInterno:MATRICOLA718 , unitaDiPersonaleEsterno:ID4789 , unitaDiPersonaleInterno:MATRICOLA507 . @prefix parolechiave: . prodotto:ID45611 parolechiave:insiemeDiParoleChiave . ns12:ID434652 pubblicazioni:rivistaDi prodotto:ID45611 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID45611 .