@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA8423 pubblicazioni:autoreCNRDi prodotto:ID4480 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS059 prodottidellaricerca:prodotto prodotto:ID4480 . @prefix modulo: . modulo:ID7274 prodottidellaricerca:prodotto prodotto:ID4480 . @prefix rdf: . @prefix retescientifica: . prodotto:ID4480 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID4480 rdfs:label "Nonrandom distribution of aberrant promoter methylation of cancer-related genes in sporadic breast tumors (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID4480 pubblicazioni:anno "2004-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1158/1078-0432.CCR-04-0555"^^xsd:string . @prefix skos: . prodotto:ID4480 skos:altLabel "
Paola Parrella,1; Maria Luana Poeta,2; Antonietta Pia Gallo,1; Maria Prencipe,1; Marina Scintu,1; Adolfo Apicella,5; Raffaele Rossiello,5; Giuseppina Liguoro,5;\nDavide Seripa,1; Carolina Gravina,1; Carla Rabitti,3; Monica Rinaldi,6; Therea Nicol,7; Stefania Tommasi,8; Angelo Paradiso,8; Francesco Schittulli,8; Vittorio Altomare,4; and Vito Michele Fazio1 (2004)
Nonrandom distribution of aberrant promoter methylation of cancer-related genes in sporadic breast tumors
in Clinical cancer research (Print)
"^^rdf:HTML ; pubblicazioni:autori "Paola Parrella,1; Maria Luana Poeta,2; Antonietta Pia Gallo,1; Maria Prencipe,1; Marina Scintu,1; Adolfo Apicella,5; Raffaele Rossiello,5; Giuseppina Liguoro,5;\nDavide Seripa,1; Carolina Gravina,1; Carla Rabitti,3; Monica Rinaldi,6; Therea Nicol,7; Stefania Tommasi,8; Angelo Paradiso,8; Francesco Schittulli,8; Vittorio Altomare,4; and Vito Michele Fazio1"^^xsd:string ; pubblicazioni:paginaInizio "5349"^^xsd:string ; pubblicazioni:paginaFine "5354"^^xsd:string ; pubblicazioni:altreInformazioni "Times Cited: 55 (from Web of Science) \n2010 IMPACT FACTOR: 7.338 \nPublisher: AMER ASSOC CANCER RESEARCH, 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA\nWeb of Science Category: Oncology\nSubject Category: Oncology\nIDS Number: 848GC\nISSN: 1078-0432"^^xsd:string ; pubblicazioni:numeroVolume "10"^^xsd:string . @prefix ns11: . prodotto:ID4480 pubblicazioni:rivista ns11:ID212584 ; pubblicazioni:numeroFascicolo "16"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "1Laboratory of Gene Therapy and Oncology, Istituto di Ricovero e Cura a Carattere Scientifico \\\"Casa Sollievo della Sofferenza,\\\" San Giovanni Rotondo (FG), Italy; \n2Laboratory of Molecular Medicine and Biotechnology;\n3Department of Pathology; and \n4Breast Unit, Department of Surgery, University \\\"Campus BioMedico,\\\" Rome Italy; \n5Department of Pathology \\\"L. Armanni\\\" II University of Naples, Naples, Italy; \n6Neurobiology and Molecular Medicine Institute, Molecular Medicine Section, Consiglio Nazionale delle Ricerche, Rome, Italy;\n7Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland; and \n8Clinical Experimental Oncology Laboratory and Department \\\"Donna,\\\" National Cancer Institute, Bari, Italy"^^xsd:string ; pubblicazioni:titolo "Nonrandom distribution of aberrant promoter methylation of cancer-related genes in sporadic breast tumors"^^xsd:string ; prodottidellaricerca:abstract "Purpose: In an effort to additionally determine the global patterns of CpG island hypermethylation in sporadic breast cancer, we searched for aberrant promoter methylation at 10 gene loci in 54 primary breast cancer and 10 breast benign lesions.\n\nExperimental Design: Genomic DNA sodium bisulfate converted from benign and malignant tissues was used as template in methyl-specific PCR for BRCA1, p16, ESR1, GSTbeta1, TRbeta1, RARbeta2, HIC1, APC, CCND2, and CDH1 genes.\n\nResults: The majority of the breast cancer (85%) showed aberrant methylation in at least I of the loci tested with half of them displaying 3 or more methylated genes. The highest frequency of aberrant promoter methylation was found for HIC1 (48%) followed by ESR1 (46%), and CDH1 (39%). Similar methylation frequencies were detected for breast benign lesions with the exception of the CDH1 gene (P = 0.02). The analysis of methyllation distribution indicates a statistically significant association between methylation of the ESR1 promoter, and methylation at CDH1, TRP1, GSTP1, and CCND2 loci (P < 0.03). Methylated status of the BRCA1 promoter was inversely correlated with methyllation at the RARbeta2 locus (P < 0.03).\n\nConclusions: Our results suggest a nonrandom distribution for promoter hypermethylation in sporadic breast cancer, with tumor subsets characterized by aberrant methylation of specific cancer-related genes. These breast cancer subgroups may represent separate biological entities with potential differences in sensitivity to therapy, occurrence of metastasis, and overall prognosis."@en ; prodottidellaricerca:prodottoDi istituto:CDS059 , modulo:ID7274 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA8423 . @prefix parolechiave: . prodotto:ID4480 parolechiave:insiemeDiParoleChiave . ns11:ID212584 pubblicazioni:rivistaDi prodotto:ID4480 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID4480 .