@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS069 prodottidellaricerca:prodotto prodotto:ID42082 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA12456 pubblicazioni:autoreCNRDi prodotto:ID42082 . unitaDiPersonaleInterno:MATRICOLA39274 pubblicazioni:autoreCNRDi prodotto:ID42082 . unitaDiPersonaleInterno:MATRICOLA29089 pubblicazioni:autoreCNRDi prodotto:ID42082 . @prefix rdf: . @prefix retescientifica: . prodotto:ID42082 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID42082 rdfs:label "UV and H202/UV degradation of a pharmaceutical intermediate in aqueoussolution (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID42082 pubblicazioni:anno "2002-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID42082 skos:altLabel "
Lopez A., Bozzi A., Mascolo G., Ciannarella R., Passino R. (2002)
UV and H202/UV degradation of a pharmaceutical intermediate in aqueoussolution
in Annali di chimica (Testo stamp.)
"^^rdf:HTML ; pubblicazioni:autori "Lopez A., Bozzi A., Mascolo G., Ciannarella R., Passino R."^^xsd:string ; pubblicazioni:paginaInizio "41"^^xsd:string ; pubblicazioni:paginaFine "51"^^xsd:string ; pubblicazioni:altreInformazioni "Le ricerche, i cui risultati sono riportati nel lavoro di riferimento, sono state avviate in seguito alla notizia, apparsa su importanti quotidiani nazionali , che in alcune falde del nord Italia erano state rilevate concentrazioni significative di intermedi di antibiotici (cefalosporine) veicolati da scarichi di impianti di depurazione"^^xsd:string ; pubblicazioni:numeroVolume "92"^^xsd:string . @prefix ns10: . prodotto:ID42082 pubblicazioni:rivista ns10:ID574088 ; pubblicazioni:descrizioneSinteticaDelProdotto "After the detection in some aquifers located in Northern Italy, the degradation of the pharmaceutical intermediate 5-methyl-1,3,4-thiadiazole-2-thiol (MMTD) has been studied by means of UV and UV/H2O2 treatments. The investigation has been carried out with a 17 W low pressure mercury lamp at room temperature, using an initial MMTD concentration of 1 mg/l and a (100)/(1) (H2O2)/(MMTD) molar ratio. The results have demonstrated that: (i) 80 % MMTD removal can be achieved within 1 hour and less than 10 minutes by UV and UV/H2O2 treatment respectively; (ii) the sole UV irradiation does not cause any MMTD mineralization; (iii) 4 hours of UV/H2O2 treatment lead to an almost complete mineralization of the MMTD organic sulfur and to a partial mineralization of carbon (59%) and nitrogen (14%). The identification of both intermediate and end by-products, performed by HPLC-UV-MS analysis, revealed that the sole UV irradiation gives rise to the MMTD transformation into a single by-product that continuously accumulates in solution. Conversely, UV/H2O2 treatment gives rise to the formation of 7 intermediates that undergo further degradation through the breakdown of the thiadiazole ring. On the basis of the obtained results a degradation pathway has been proposed"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "CNR \u0096 Istituto di Ricerca sulle Acque"^^xsd:string ; pubblicazioni:titolo "UV and H202/UV degradation of a pharmaceutical intermediate in aqueoussolution"^^xsd:string ; prodottidellaricerca:abstract "The degradation of 5-methyl-1,3,4-thiadiazole-2-thiol (NMTD), a pharmaceutical intermediate found in some aquifers of Northern Italy, has been investigated by means of UV and UV/H2O2 treatments. The study has been carried out with a 17 W low pressure mercury lamp at room temperature, using a (100)/(1)(H2O2)/(MMTD) molar ratio. The results have demonstrated that: (i) with an initial MMTD concentration of 1 mg/1, 90 % MMTD removal can be achieved within 1 hour or less than 5 minutes by UV or UV/H2O2 respectively; (ii) the sole UV irradiation does not cause any MMTD mineralization; (iii) with an initial MMTD concentration of 50 mg/1, 4 hours of UV/H2O2 treatment lead to an almost complete mineralization of the MMTD organic sulfur and to a partial mineralization of carbon (59%) and nitrogen (14%). The identification of degradation by-products, performed by HPLC-UV-MS analysis, revealed that the sole UV irradiation gives rise to the MMTD transformation into a single by-product that continuously accumulates in the solution. Conversely, the UV/H2O2 treatment forms seven intermediates that undergo further degradation through the breakdown of the thiadiazole ring. On the basis of the obtained results a degradation pathway has been proposed" ; prodottidellaricerca:prodottoDi istituto:CDS069 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA39274 , unitaDiPersonaleInterno:MATRICOLA12456 , unitaDiPersonaleInterno:MATRICOLA29089 . @prefix parolechiave: . prodotto:ID42082 parolechiave:insiemeDiParoleChiave . ns10:ID574088 pubblicazioni:rivistaDi prodotto:ID42082 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID42082 .