@prefix pubblicazioni: . @prefix unitaDiPersonaleEsterno: . @prefix prodotto: . unitaDiPersonaleEsterno:ID1779 pubblicazioni:autoreCNRDi prodotto:ID37815 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS061 prodottidellaricerca:prodotto prodotto:ID37815 . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA7301 pubblicazioni:autoreCNRDi prodotto:ID37815 . unitaDiPersonaleEsterno:ID1851 pubblicazioni:autoreCNRDi prodotto:ID37815 . @prefix modulo: . modulo:ID2648 prodottidellaricerca:prodotto prodotto:ID37815 . @prefix rdf: . @prefix retescientifica: . prodotto:ID37815 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID37815 rdfs:label "Brain neuronal nicotinic receptors as new targets for drug discovery. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID37815 pubblicazioni:anno "2006-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.2174/138161206775474486"^^xsd:string . @prefix skos: . prodotto:ID37815 skos:altLabel "
Gotti C; Riganti L; Vailati S; and Clementi F (2006)
Brain neuronal nicotinic receptors as new targets for drug discovery.
in Current pharmaceutical design (Print)
"^^rdf:HTML ; pubblicazioni:autori "Gotti C; Riganti L; Vailati S; and Clementi F"^^xsd:string ; pubblicazioni:paginaInizio "407"^^xsd:string ; pubblicazioni:paginaFine "428"^^xsd:string ; pubblicazioni:numeroVolume "12"^^xsd:string . @prefix ns12: . prodotto:ID37815 pubblicazioni:rivista ns12:ID221457 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "CNR, Inst Neurosci, Sect Cellular & Mol Pharmacol,Dept Med Pharmacol, Via Vanvitelli 32, I-20129 Milan, Italy"^^xsd:string ; pubblicazioni:titolo "Brain neuronal nicotinic receptors as new targets for drug discovery."^^xsd:string ; prodottidellaricerca:abstract "Neuronal nicotinic receptors (nAChRs) are a heterogeneous family of ion channels differently expressed in the nervous system where, by responding to the endogenous neurotransmitter acetylcholine, they contribute to a wide range of brain activities and influence a number of physiological functions. \n\nOver recent years, the application of newly developed molecular and cellular biological techniques has made it possible to correlate the subunit composition of nAChRs with specific nicotine-elicited behaviours, and refine some of the in vivo physiological functions of nAChR subtypes. The major new findings are the widespread expression of nAChRs, outside the nervous system, their specific and complex organisation, and their relevance to normal brain function. Moreover, the combination of clinical and basic research has better defined the involvement of nAChRs in a growing number of nervous pathologies other than degenerative diseases. \n\nHowever, there are still only a limited number of nicotinic-specific drugs and, although some nicotinic agonists have an interesting pharmacology, their clinical use is limited by undesirable side effects. Some selective nicotinic ligands have recently been developed and used to explore the complexity of nAChR subtype structure and function in the expectation that they will become rational therapeutic alternatives in a number of neurodegenerative, neuropsychiatric and neurological disorders. \n\nIn this review, we will discuss the molecular basis of brain nAChR structural and functional diversity mainly in pharmacological and biochemical terms, and summarise current knowledge concerning the newly discovered drugs used to classify the numerous receptor subtypes and treat the brain diseases in which nAChRs are involved."@en ; prodottidellaricerca:prodottoDi istituto:CDS061 , modulo:ID2648 ; pubblicazioni:autoreCNR unitaDiPersonaleEsterno:ID1851 , unitaDiPersonaleInterno:MATRICOLA7301 , unitaDiPersonaleEsterno:ID1779 . @prefix parolechiave: . prodotto:ID37815 parolechiave:insiemeDiParoleChiave . ns12:ID221457 pubblicazioni:rivistaDi prodotto:ID37815 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID37815 .