@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS061 prodottidellaricerca:prodotto prodotto:ID37809 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA18543 pubblicazioni:autoreCNRDi prodotto:ID37809 . unitaDiPersonaleInterno:MATRICOLA6865 pubblicazioni:autoreCNRDi prodotto:ID37809 . @prefix modulo: . modulo:ID2648 prodottidellaricerca:prodotto prodotto:ID37809 . @prefix rdf: . @prefix retescientifica: . prodotto:ID37809 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID37809 rdfs:label "The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID37809 pubblicazioni:anno "2006-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID37809 skos:altLabel "
Ciana P, Fumagalli M, Trincavelli ML, Verderio C, Rosa P, Lecca D, Ferrario S, Parravicini C, Capra V, Gelosa P, Guerrini U, Belcredito S, Cimino M, Sironi L, Tremoli E, Rovati GE, Martini C and Abbracchio MP (2006)
The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor.
in EMBO journal (Print)
"^^rdf:HTML ; pubblicazioni:autori "Ciana P, Fumagalli M, Trincavelli ML, Verderio C, Rosa P, Lecca D, Ferrario S, Parravicini C, Capra V, Gelosa P, Guerrini U, Belcredito S, Cimino M, Sironi L, Tremoli E, Rovati GE, Martini C and Abbracchio MP"^^xsd:string ; pubblicazioni:paginaInizio "4615"^^xsd:string ; pubblicazioni:paginaFine "4627"^^xsd:string ; pubblicazioni:numeroVolume "25"^^xsd:string . @prefix ns11: . prodotto:ID37809 pubblicazioni:rivista ns11:ID434597 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "1. Univ Milan, Dept Pharmacol Sci, I-20133 Milan, Italy \n2. Univ Pisa, Dept Psychiat Neurobiol Pharmacol & Biotechnol, Pisa, Italy \n3. Univ Milan, Dept Med Pharmacol, CNR, Inst Neurosci Cellular & Mol Pharmacol, Milan, Italy \n4. Univ Urbino, Inst Pharmacol & Pharmacognosy, I-61029 Urbino, Italy \n5. IRCCS, Monzino Cardiol Ctr, Milan, Italy"^^xsd:string ; pubblicazioni:titolo "The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor."^^xsd:string ; prodottidellaricerca:abstract "Nucleotides and cysteinyl-leukotrienes (CysLTs) are unrelated signaling molecules inducing multiple effects through separate G-protein-coupled receptors: the P2Y and the CysLT receptors. Here we show that GPR17, a Gi-coupled orphan receptor at intermediate phylogenetic position between P2Y and CysLT receptors, is specifically activated by both families of endogenous ligands, leading to both adenylyl cyclase inhibition and intracellular calcium increases. Agonist-response profile, as determined by [S-35] GTP gamma S binding, was different from that of already known CysLT and P2Y receptors, with EC50 values in the nanomolar and micromolar range, for CysLTs and uracil nucleotides, respectively. Both rat and human receptors are highly expressed in the organs typically undergoing ischemic damage, that is, brain, heart and kidney. In vivo inhibition of GPR17 by either CysLT/P2Y receptor antagonists or antisense technology dramatically reduced ischemic damage in a rat focal ischemia model, suggesting GPR17 as the common molecular target mediating brain damage by nucleotides and CysLTs. In conclusion, the deorphanization of GPR17 revealed a dualistic receptor for two endogenous unrelated ligand families. These findings may lead to dualistic drugs of previously unexplored therapeutic potential." ; prodottidellaricerca:prodottoDi modulo:ID2648 , istituto:CDS061 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA18543 , unitaDiPersonaleInterno:MATRICOLA6865 . ns11:ID434597 pubblicazioni:rivistaDi prodotto:ID37809 .