@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA29473 pubblicazioni:autoreCNRDi prodotto:ID37674 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS061 prodottidellaricerca:prodotto prodotto:ID37674 . @prefix rdf: . @prefix retescientifica: . prodotto:ID37674 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID37674 rdfs:label "Sardinian alcohol-preferring and non-preferring rats show different reactivity to aversive stimuli and a similar response to a natural reward. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID37674 pubblicazioni:anno "2003-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID37674 skos:altLabel "
Leggio B. 1, Masi F. 1, Grappi S. 1, Nanni G. 1, Gambarana C. 1, Colombo G. 2, De Montis M.G. 1 (2003)
Sardinian alcohol-preferring and non-preferring rats show different reactivity to aversive stimuli and a similar response to a natural reward.
in Brain research
"^^rdf:HTML ; pubblicazioni:autori "Leggio B. 1, Masi F. 1, Grappi S. 1, Nanni G. 1, Gambarana C. 1, Colombo G. 2, De Montis M.G. 1"^^xsd:string ; pubblicazioni:paginaInizio "275"^^xsd:string ; pubblicazioni:paginaFine "284"^^xsd:string ; pubblicazioni:numeroVolume "973"^^xsd:string . @prefix ns10: . prodotto:ID37674 pubblicazioni:rivista ns10:ID392946 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:titolo "Sardinian alcohol-preferring and non-preferring rats show different reactivity to aversive stimuli and a similar response to a natural reward."^^xsd:string ; prodottidellaricerca:abstract "Sardinian alcohol-preferring (sP) and non-preferring (sNP) rats were studied to ascertain whether some behavioral and/or neurochemical traits, beyond ethanol preference, differentiated the two lines. Spontaneous reactivity of Wistar, sP and sNP rats to aversive or pleasurable stimuli was examined in an avoidance test, an elevated plus maze test, and in response to palatable food presentation. As the mesocorticolimbic dopaminergic system plays a relevant role in the response to rewarding or aversive stimuli, extraneuronal dopamine levels and cocaine-induced dopamine accumulation in the nucleus accumbens shell (NAcS) and medial prefrontal cortex (mPFC) were studied by microdialysis in the three groups of rats. Moreover, rats were exposed to repeated unavoidable stress and their avoidance response and NAcS dopamine output were determined. Finally, the capacity of sP, sNP, and Wistar rats to learn a palatable food-sustained appetitive behavior was studied. The present study shows that, beyond ethanol preference, there are several behavioral and neurochemical distinctions between sP and sNP rats. The sP rats displayed an increased level of anxiety-like behavior and sNP rats showed a reduced avoidance of noxious stimuli, compared to Wistar rats. Moreover, in the NAcS and PFC, extraneuronal dopamine levels were higher in sP rats and lower in sNP rats compared to Wistar rats; cocaine-induced dopamine accumulation in the NAcS was higher in sP rats than in sNP and Wistar rats. However, sP and sNP rats showed a similar behavioral and neurochemical response to chronic unavoidable stress. Interestingly, they also showed similar behavioral and neurochemical responses to a natural rewarding stimulus and a similar ability to learn an appetitive behavior." ; prodottidellaricerca:prodottoDi istituto:CDS061 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA29473 . ns10:ID392946 pubblicazioni:rivistaDi prodotto:ID37674 .