@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA8960 pubblicazioni:autoreCNRDi prodotto:ID37661 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS061 prodottidellaricerca:prodotto prodotto:ID37661 . @prefix rdf: . @prefix retescientifica: . prodotto:ID37661 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID37661 rdfs:label "Social isolation-induced increase in the sensitivity of rats to the steroidogenic effect of ethanol. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID37661 pubblicazioni:anno "2003-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID37661 skos:altLabel "
Serra M. 1, Pisu M.G. 2, Floris I.1, Cara V. 1, Purdy R.H. 3, Biggio G.1 (2003)
Social isolation-induced increase in the sensitivity of rats to the steroidogenic effect of ethanol.
in Journal of neurochemistry
"^^rdf:HTML ; pubblicazioni:autori "Serra M. 1, Pisu M.G. 2, Floris I.1, Cara V. 1, Purdy R.H. 3, Biggio G.1"^^xsd:string ; pubblicazioni:paginaInizio "257"^^xsd:string ; pubblicazioni:paginaFine "263"^^xsd:string ; pubblicazioni:altreInformazioni "I.F. = 4.969"^^xsd:string ; pubblicazioni:numeroVolume "85(1)"^^xsd:string . @prefix ns10: . prodotto:ID37661 pubblicazioni:rivista ns10:ID294125 ; pubblicazioni:descrizioneSinteticaDelProdotto "articolo su rivista internazionale"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "1 Uni Cagliari, 2 CNR, 3 Uni San Diego"^^xsd:string ; pubblicazioni:titolo "Social isolation-induced increase in the sensitivity of rats to the steroidogenic effect of ethanol."^^xsd:string ; prodottidellaricerca:abstract "Social isolation of rats for 30 days immediately after weaning results in marked decreases in the cerebrocortical and plasma concentrations of pregnenolone, progesterone, 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-TH PROG), and 3alpha,5alpha-tetrahydrodeoxycorticosterone (3alpha,5alpha-TH DOC), as well as a moderate increase in the plasma concentration of corticosterone. This mildly stressful condition has now been shown to increase the sensitivity of rats to the effect of acute ethanol administration on the cerebrocortical and plasma concentrations of neuroactive steroids. The percentage increases in the brain and plasma concentrations of pregnenolone, progesterone, 3alpha,5alpha-TH PROG, and 3alpha,5alpha-TH DOC, apparent 20 min after a single intraperitoneal injection of ethanol (1 g/kg), were thus markedly greater in isolated rats than in group-housed animals. A subcutaneous injection of isoniazid (300 mg/kg) also induced greater percentage increases in the concentrations of these steroids in isolated rats than in group-housed animals. These results suggest that mild chronic stress, such as that induced by social isolation, enhances the steroidogenic effect of ethanol, a drug abused by humans under stress or affected by neuropsychiatric disorders. Social isolation also induced hyper-responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis, as was apparent after reduction of GABA-mediated inhibitory tone by isoniazid administration."@en ; prodottidellaricerca:prodottoDi istituto:CDS061 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA8960 . @prefix parolechiave: . prodotto:ID37661 parolechiave:insiemeDiParoleChiave . ns10:ID294125 pubblicazioni:rivistaDi prodotto:ID37661 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID37661 .