@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS061 prodottidellaricerca:prodotto prodotto:ID37659 . @prefix rdf: . @prefix retescientifica: . prodotto:ID37659 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID37659 rdfs:label "Synthesis of novel diazatricyclodecanes (DTDs). Effects of structural variation at the C3' allyl end and at the phenyl ring of the cinnamyl chain on mu-receptor affinity and opioid antinociception (Articolo in rivista)"@en . @prefix xsd: . @prefix pubblicazioni: . prodotto:ID37659 pubblicazioni:anno "2003-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID37659 skos:altLabel "
Pinna GA, Cignarella G, Ruiu S, Loriga G, Murineddu G, Villa S, Grella GE, Cossu G, Fratta W. (2003)
Synthesis of novel diazatricyclodecanes (DTDs). Effects of structural variation at the C3' allyl end and at the phenyl ring of the cinnamyl chain on mu-receptor affinity and opioid antinociception
in Bioorganic & medicinal chemistry (Print)
"^^rdf:HTML ; pubblicazioni:autori "Pinna GA, Cignarella G, Ruiu S, Loriga G, Murineddu G, Villa S, Grella GE, Cossu G, Fratta W."^^xsd:string ; pubblicazioni:paginaInizio "4015"^^xsd:string ; pubblicazioni:paginaFine "4026"^^xsd:string ; pubblicazioni:numeroVolume "11"^^xsd:string . @prefix ns9: . prodotto:ID37659 pubblicazioni:rivista ns9:ID238380 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:titolo "Synthesis of novel diazatricyclodecanes (DTDs). Effects of structural variation at the C3' allyl end and at the phenyl ring of the cinnamyl chain on mu-receptor affinity and opioid antinociception"^^xsd:string ; prodottidellaricerca:abstract "Two series of analogues of 9-propionyl-10-cinnamyl-9,10-diazatricyclo[4.2.1.1(2,5)]decane (1a) and 2-propionyl-7-cinnamyl-2,7-diazatricyclo[4.4.0.0(3,8)]decane (2a), in which the cinnamyl moiety was replaced by various aralkenyl chains, 1b-l and 2b-l, respectively, have been synthesized and evaluated for their ability to bind to the opioid mu-, delta- and kappa-receptors. The binding data indicated that compounds 1b,d,e,h and 2b,d,e,f,h,i showed a mu-affinity in the low nanomolar range with moderate or negligible affinity towards delta- and kappa-receptors. Selected DTDs, the pairs 1,2b, 1,2e and 1,2h, were also evaluated for analgesic effect. In the hot plate test, only 1b given ip was found to have similar opioid antinociception and chronic tolerance as morphine.\n" ; prodottidellaricerca:prodottoDi istituto:CDS061 . ns9:ID238380 pubblicazioni:rivistaDi prodotto:ID37659 .